ArticleAJNR. American journal of neuroradiology2012
Vertebral endplate changes are not associated with chronic low back pain among Southern European subjects: a case control study.
Article in AJNR. American journal of neuroradiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Modic changes-Their associations with low back pain and activity limitation: A systematic literature review and meta-analysis.PloS one · 2018Pooled it
- Systematic literature review of imaging features of spinal degeneration in asymptomatic populations.AJNR. American journal of neuroradiology · 2015Pooled it
- Trial
- ISSLS Prize in Bioengineering Science 2026: Hidden in Plain Sight: Machine Learning-Assisted MRI Reveals Novel Vertebral Body Biomarkers of Chronic Low Back Pain in Humans.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Review
- Human molecular mechanisms of discogenic low back pain: A scoping review.The journal of pain · 2025Article
- Study of the Distribution of Lumbar Modic Changes in Patients with Low Back Pain and Correlation with Lumbar Degeneration Diseases [Response to Letter].Journal of pain research · 2024Article
- Re: Study of the Distribution of Lumbar Modic Changes in Patients with Low Back Pain and Correlation with Lumbar Degeneration Diseases [Letter].Journal of pain research · 2023Article
- The association of modic changes and chronic low back pain: A systematic review.Journal of orthopaedics · 2023Review
- Detailed Subphenotyping of Lumbar Modic Changes and Their Association with Low Back Pain in a Large Population-Based Study: The Wakayama Spine Study.Pain and therapy · 2022Article
- Methodological concerns of "Intra-osseous basivertebral nerve radiofrequency ablation (BVA) for the treatment of vertebrogenic chronic low back pain".Neuroradiology · 2021Article
- Association between types of Modic changes in the lumbar region and low back pain in a large cohort: the Wakayama spine study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2021Article
- Spinal fusion on adolescent idiopathic scoliosis patients with the level of L4 or lower can increase lumbar disc degeneration with sagittal imbalance 35 years after surgery.Spine surgery and related research · 2017Article
- Refined Phenotyping of Modic Changes: Imaging Biomarkers of Prolonged Severe Low Back Pain and Disability.Medicine · 2016Observational
- Association between changes in lumbar Modic changes and low back symptoms over a two-year period.BMC musculoskeletal disorders · 2015Article
- Longitudinal associations between incident lumbar spine MRI findings and chronic low back pain or radicular symptoms: retrospective analysis of data from the longitudinal assessment of imaging and disability of the back (LAIDBACK).BMC musculoskeletal disorders · 2014Article
- Disc degeneration and chronic low back pain: an association which becomes nonsignificant when endplate changes and disc contour are taken into account.Neuroradiology · 2014Article
- [Degenerative alterations of the spinal column: rational imaging].Der Internist · 2013Article
- Reply: To PMID 22499847.AJNR. American journal of neuroradiology · 2013Article
- Paternalism in radiology?AJNR. American journal of neuroradiology · 2013Article
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeData on the association between vertebral endplate changes and low back pain are contradictory. This study was designed to assess whether this association exists among Southern European subjects. MATERIALS AND
methodsPatients in this study serving as cases were 35-50 years of age with low back pain lasting >90 days, for whom a lumbar MR imaging had been prescribed. Controls were subjects 35-50 years of age, having a cranial MR imaging for headache with normal findings, and no history of clinically relevant LBP. Two hundred forty cases and 64 controls were recruited consecutively in the radiology services across 6 cities in Spain. Imaging findings and subject characteristics were gathered through previously validated instruments. Radiologists who interpreted MRI were blinded to the subject characteristics. A multivariate logistic regression model was developed to assess the association of vertebral endplate changes with LBP, adjusting for sex, age, body mass index, lifetime exposure to smoking, physical activity, disk degeneration, and the interaction between disk degeneration and vertebral endplate changes.
resultsVertebral endplate changes were found in 80.4% of the cases and in 87.5% of the controls. In the regression model, disk degeneration was the only variable showing a confounding effect. Results showed that after adjusting for disk degeneration, the presence of vertebral endplate changes is associated with the absence of chronic LBP (OR for LBP: 0.31; 95% CI, 0.10-0.95).
conclusionsIn Southern European subjects, vertebral endplate changes are not associated with chronic LBP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.