ArticleCerebral cortex (New York, N.Y. : 1991)2013
Deletion of Ten-m3 induces the formation of eye dominance domains in mouse visual cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Microglia: Mediators of experience-driven corrective neuroplasticity.IBRO neuroscience reports · 2025Article
- Differential Expression Analysis Identifies Candidate Synaptogenic Molecules for Wiring Direction-Selective Circuits in the Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Synaptic promiscuity in brain development.Current biology : CB · 2024Review
- Development of ocular dominance columns across rodents and other species: revisiting the concept of critical period plasticity.Frontiers in neural circuits · 2024Review
- Teneurin trans-axonal signaling prunes topographically missorted axons.Cell reports · 2023Article
- Cortical feedback modulates distinct critical period development in mouse visual thalamus.iScience · 2023Article
- Article
- Teneurins assemble into presynaptic nanoclusters that promote synapse formation via postsynaptic non-teneurin ligands.Nature communications · 2022Article
- Environmental Enrichment Rescues Visually-Mediated Behavior in Ten-m3 Knockout Mice During an Early Critical Period.Frontiers in behavioral neuroscience · 2020Article
- Diversity of Ocular Dominance Patterns in Visual Cortex Originates from Variations in Local Cortical Retinotopy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Development and Arealization of the Cerebral Cortex.Neuron · 2019Review
- Teneurins: Mediators of Complex Neural Circuit Assembly in Mammals.Frontiers in neuroscience · 2019Article
- Thalamocortical Circuits and Functional Architecture.Annual review of vision science · 2018Review
- Article
- Teneurins: Domain Architecture, Evolutionary Origins, and Patterns of Expression.Frontiers in neuroscience · 2018Review
- Teneurins: An Integrative Molecular, Functional, and Biomedical Overview of Their Role in Cancer.Frontiers in neuroscience · 2018Review
- Identification of Eye-Specific Domains and Their Relation to Callosal Connections in Primary Visual Cortex of Long Evans Rats.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Comprehensive identification and analysis of human accelerated regulatory DNA.Genome research · 2015Article
- On the Teneurin track: a new synaptic organization molecule emerges.Frontiers in cellular neuroscience · 2015Review
- Latrophilins function as heterophilic cell-adhesion molecules by binding to teneurins: regulation by alternative splicing.The Journal of biological chemistry · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The visual system is characterized by precise retinotopic mapping of each eye, together with exquisitely matched binocular projections. In many species, the inputs that represent the eyes are segregated into ocular dominance columns in primary visual cortex (V1), whereas in rodents, this does not occur. Ten-m3, a member of the Ten-m/Odz/Teneurin family, regulates axonal guidance in the retinogeniculate pathway. Significantly, ipsilateral projections are expanded in the dorsal lateral geniculate nucleus and are not aligned with contralateral projections in Ten-m3 knockout (KO) mice. Here, we demonstrate the impact of altered retinogeniculate mapping on the organization and function of V1. Transneuronal tracing and c-fos immunohistochemistry demonstrate that the subcortical expansion of ipsilateral input is conveyed to V1 in Ten-m3 KOs: Ipsilateral inputs are widely distributed across V1 and are interdigitated with contralateral inputs into eye dominance domains. Segregation is confirmed by optical imaging of intrinsic signals. Single-unit recording shows ipsilateral, and contralateral inputs are mismatched at the level of single V1 neurons, and binocular stimulation leads to functional suppression of these cells. These findings indicate that the medial expansion of the binocular zone together with an interocular mismatch is sufficient to induce novel structural features, such as eye dominance domains in rodent visual cortex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.