ArticleProceedings of the National Academy of Sciences of the United States of America2012
Probing the stability of nonglycosylated wild-type erythropoietin protein via reiterative alanine ligations.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- Fully Synthetic Granulocyte Colony-Stimulating Factor Enabled by Isonitrile-Mediated Coupling of Large, Side-Chain-Unprotected Peptides.Journal of the American Chemical Society · 2015Article
- Total synthesis of glycosylated proteins.Topics in current chemistry · 2015Review
- Cysteine promoted C-terminal hydrazinolysis of native peptides and proteins.Angewandte Chemie (International ed. in English) · 2013Article
- The winding pathway to erythropoietin along the chemistry-biology frontier: a success at last.Angewandte Chemie (International ed. in English) · 2013Review
- At last: erythropoietin as a single glycoform.Angewandte Chemie (International ed. in English) · 2012Article
- An advance in the chemical synthesis of homogeneous N-linked glycopolypeptides by convergent aspartylation.Angewandte Chemie (International ed. in English) · 2012Article
- Engineering of therapeutic polypeptides through chemical synthesis: early lessons from human parathyroid hormone and analogues.Journal of the American Chemical Society · 2012Article
- Revisiting oxytocin through the medium of isonitriles.Journal of the American Chemical Society · 2012Article
- From EPOthilone to EPO: Aa challenge for natural product synthesis.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Nonglycosylated erythropoietin bearing acetamidomethyl protecting groups at the cysteine residues has been synthesized via chemical methods. Alanine ligation was used to assemble four peptide fragments, themselves prepared by solid phase peptide synthesis. This work outlines a route for the synthesis of homogeneous glycosylated erythropoietin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.