ArticleStatistical applications in genetics and molecular biology2012
Improving pedigree-based linkage analysis by estimating coancestry among families.
Article in Statistical applications in genetics and molecular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Pedigree-Free Descent-Based Gene Mapping from Population Samples.Human heredity · 2015Article
- Joint inference of identity by descent along multiple chromosomes from population samples.Journal of computational biology : a journal of computational molecular cell biology · 2014Article
- Efficient identification of equivalences in dynamic graphs and pedigree structures.Journal of computational biology : a journal of computational molecular cell biology · 2013Article
- Review
- Identity-by-descent-based heritability analysis in the Northern Finland Birth Cohort.Human genetics · 2013Article
- Inferring coancestry in population samples in the presence of linkage disequilibrium.Genetics · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We present a method for improving the power of linkage analysis by detecting chromosome segments shared identical by descent (IBD) by individuals not known to be related. Existing Markov chain Monte Carlo methods sample descent patterns on pedigrees conditional on observed marker data. These patterns can be stored as IBD graphs, which express shared ancestry only, rather than specific family relationships. A model for IBD between unrelated individuals allows the estimation of coancestry between individuals in different pedigrees. IBD graphs on separate pedigrees can then be combined using these estimates. We report results from analyses of three sets of simulated marker data on two different pedigrees. We show that when families share a gene for a trait due to shared ancestry on the order of tens of generations, our method can detect a linkage signal when independent analyses of the families do not.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.