ArticleGenome research2012
Genome-wide analysis of mutations in mutant lineages selected following fast-neutron irradiation mutagenesis of Arabidopsis thaliana.
Article in Genome research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed, 149 citations in OpenAlex.
- KitBase Expanded: An Integrated Genomic and Phenotypic Resource for 3,268 Fast-Neutron-Irradiated Rice Mutants.Database : the journal of biological databases and curation · 2026Article
- The impact of carbon-ion beam irradiation on the phenotypic and molecular variation of wheat.BMC plant biology · 2025Article
- Manipulating alternative end-joining alters carbon-ion beam-induced genome mutation profiles in Arabidopsis thaliana.DNA research : an international journal for rapid publication of reports on genes and genomes · 2025Article
- Sodium azide mutagenesis induces a unique pattern of mutations.PLoS genetics · 2025Article
- Effects of acute and chronic gamma irradiations on regeneration of tissue types from selected Ugandan cassava genotypes.Frontiers in plant science · 2025Article
- Global characterization of somatic mutations and DNA methylation changes during vegetative propagation in strawberries.Genome research · 2024Article
- Genotyping by sequencing; a strategy for identification and mapping of induced mutation in newly developed wheat mutant lines.Functional & integrative genomics · 2024Article
- Furfural tolerance of mutant Saccharomyces cerevisiae selected via ionizing radiation combined with adaptive laboratory evolution.Biotechnology for biofuels and bioproducts · 2024Article
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- Genome organization and botanical diversity.The Plant cell · 2024Review
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- Genomics of predictive radiation mutagenesis in oilseed rape: modifying seed oil composition.Plant biotechnology journal · 2024Article
- Plant Functional Genomics Based on High-Throughput CRISPR Library Knockout Screening: A Perspective.Advanced genetics (Hoboken, N.J.) · 2024Article
- Enhancing cold resistance in Banana (Musa spp.) through EMS-induced mutagenesis, L-Hyp pressure selection: phenotypic alterations, biomass composition, and transcriptomic insights.BMC plant biology · 2024Article
- A chromosome 16 deletion conferring a high sucrose phenotype in soybean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Comparative analysis of seed and seedling irradiation with gamma rays and carbon ions for mutation induction in Arabidopsis.Frontiers in plant science · 2023Article
- Ultra-high static magnetic field induces a change in the spectrum but not frequency of DNA spontaneous mutations inFrontiers in plant science · 2023Article
- Genome-wide analysis of mutations induced by carbon ion beam irradiation in cotton.Frontiers in plant science · 2023Article
- Fast neutron mutagenesis in soybean enriches for small indels and creates frameshift mutations.G3 (Bethesda, Md.) · 2022Article
- Frequency and Spectrum of Mutations Induced by Gamma Rays Revealed by Phenotype Screening and Whole-Genome Re-Sequencing inInternational journal of molecular sciences · 2022Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 4 countries.
Funding
Abstract
Ionizing radiation has long been known to induce heritable mutagenic change in DNA sequence. However, the genome-wide effect of radiation is not well understood. Here we report the molecular properties and frequency of mutations in phenotypically selected mutant lines isolated following exposure of the genetic model flowering plant Arabidopsis thaliana to fast neutrons (FNs). Previous studies suggested that FNs predominantly induce deletions longer than a kilobase in A. thaliana. However, we found a higher frequency of single base substitution than deletion mutations. While the overall frequency and molecular spectrum of fast-neutron (FN)-induced single base substitutions differed substantially from those of "background" mutations arising spontaneously in laboratory-grown plants, G:C>A:T transitions were favored in both. We found that FN-induced G:C>A:T transitions were concentrated at pyrimidine dinucleotide sites, suggesting that FNs promote the formation of mutational covalent linkages between adjacent pyrimidine residues. In addition, we found that FNs induced more single base than large deletions, and that these single base deletions were possibly caused by replication slippage. Our observations provide an initial picture of the genome-wide molecular profile of mutations induced in A. thaliana by FN irradiation and are particularly informative of the nature and extent of genome-wide mutation in lines selected on the basis of mutant phenotypes from FN-mutagenized A. thaliana populations.
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