ArticleGenome research2012
Disentangling the relationship between sex-biased gene expression and X-linkage.
Article in Genome research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
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Who cites it
92 citing papers in PubMed, 155 citations in OpenAlex.
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- Species-rich and genomically diverse: comparative genomics reveals how fusions, fissions, and sex chromosomes have shaped beetle evolution.bioRxiv : the preprint server for biology · 2026Article
- Adaptive gene expression parallelism in the male reproductive tract of two Drosophila species.Genetics · 2025Article
- Genome-wide identification of selection signatures across altitudinal gradients in dairy sheep breeds.Scientific reports · 2025Article
- An Extension of Muller's Sheltering Hypothesis for the Evolution of Sex Chromosome Gene Content.Molecular biology and evolution · 2025Article
- Dichotomous transcriptome divergence at the cell-type level between thebioRxiv : the preprint server for biology · 2025Article
- Expression Divergence in Response to Sex-biased Selection.Molecular biology and evolution · 2025Article
- Improved sampling of genotypes and species reveals new insights on de novo gene history and regulatory origins.Genetics · 2025Article
- Quantifying Transcriptome Turnover on Phylogenies by Modeling Gene Expression as a Binary Trait.Molecular biology and evolution · 2025Article
- Dynamics of X chromosome hyper-expression and inactivation in male tissues during stick insect development.PLoS genetics · 2025Article
- Selection with two alleles of X-linkage and its application to the fitness component analysis of OdsH in Drosophila.G3 (Bethesda, Md.) · 2024Article
- Evolution of sex-biased genes inEcology and evolution · 2024Article
- Positive Selection Drives cis-regulatory Evolution Across the Threespine Stickleback Y Chromosome.Molecular biology and evolution · 2024Article
- Two Forms of Sexual Dimorphism in Gene Expression in Drosophila melanogaster: Their Coincidence and Evolutionary Genetics.Molecular biology and evolution · 2023Article
- Sex-biased gene expression in nutrient-sensing pathways.Proceedings. Biological sciences · 2023Article
- Ancient homomorphy of molluscan sex chromosomes sustained by reversible sex-biased genes and sex determiner translocation.Nature ecology & evolution · 2022Article
- Induction and inhibition of Drosophila X chromosome gene expression are both impeded by the dosage compensation complex.G3 (Bethesda, Md.) · 2022Article
- Chromatin landscape associated with sexual differentiation in a UV sex determination system.Nucleic acids research · 2022Article
- Support for faster and more adaptive Z chromosome evolution in two divergent lepidopteran lineagesEvolution; international journal of organic evolution · 2022Article
- Population biology of accessory gland-expressed de novo genes in Drosophila melanogaster.Genetics · 2022Article
32 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
X chromosomes are preferentially transmitted through females, which may favor the accumulation of X-linked alleles/genes with female-beneficial effects. Numerous studies have shown that genes with sex-biased expression are under- or over-represented on the X chromosomes of a wide variety of organisms. The patterns, however, vary between different animal species, and the causes of these differences are unresolved. Additionally, genes with sex-biased expression tend to be narrowly expressed in a limited number of tissues, and narrowly expressed genes are also non-randomly X-linked in a taxon-specific manner. It is therefore unclear whether the unique gene content of the X chromosome is the result of selection on genes with sex-biased expression, narrowly expressed genes, or some combination of the two. To address this problem, we measured sex-biased expression in multiple Drosophila species and at different developmental time points. These data were combined with available expression measurements from Drosophila melanogaster and mouse to reconcile the inconsistencies in X-chromosome content among taxa. Our results suggest that most of the differences between Drosophila and mammals are confounded by disparate data collection/analysis approaches as well as the correlation between sex bias and expression breadth. Both the Drosophila and mouse X chromosomes harbor an excess of genes with female-biased expression after controlling for the confounding factors, suggesting that the asymmetrical transmission of the X chromosome favors the accumulation of female-beneficial mutations in X-linked genes. However, some taxon-specific patterns remain, and we provide evidence that these are in part a consequence of constraints imposed by the dosage compensation mechanism in Drosophila.
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