Evidence map›Paper›PMID 22499458›Full record

ArticleThe journal of nutrition, health & aging2012

Recruitment strategies for preventive trials. The MAPT study (MultiDomain Alzheimer Preventive Trial).

I Carrié, G Abellan van Kan, S Gillette-Guyonnet, S Andrieu, J-F Dartigues, J Touchon, T Dantoine, O Rouaud, M Bonnefoy, P Robert and 8 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of nutrition, health & aging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Cognitive interventions targeting subjective cognitive complaints.American journal of Alzheimer's disease and other dementias · 2013
    Pooled it
  8. Trial
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  11. Review
  12. Article
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  20. Precision Medicine for Alzheimer's Disease Prevention.Healthcare (Basel, Switzerland) · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

I CarriéGérontopôle, Departement of Geriatrics, CHU Toulouse, Purpan University Hospital, Toulouse, France.
G Abellan van Kan
S Gillette-Guyonnet
S Andrieu
J-F Dartigues
J Touchon
T Dantoine
O Rouaud
M Bonnefoy
P Robert
M-N Cuffi
L Bories
S Bordes
Y Gasnier
F Desclaux
K Sudres
A Pesce
B Vellas

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

1680 participants were randomized over the recruitment period in MAPT study. A total of 1290 participants were recruited in the 7 University Hospital centers, and 390 participants in the 6 memory clinics around Toulouse Gerontopole / Alzheimer Disease research clinical center. The first randomization was on May 30, 2008, and the targeted number of randomized participants was reached on February 24, 2011; 2595 subjects were finally screened, of which 1680 fulfilled the eligibility criteria which represents 64.8%. Approximately, one quarter of screened people refused to participate after the detailed presentation of the study and 4.3% were still interested in participating but missed for unknown reasons the baseline visit even after repeated contacts. Of the 1810 subjects who signed the consent for participating to the study at the baseline visit, 130 (7.1%) were excluded because one of the eligibility criteria was not satisfied. Interestingly, the higher percentage of randomizations compared to screened participants is the personal contact source; almost 85 % of screened participants entered in the study. In an equivalent way, Medias and conferences are efficient recruiting sources to enrol volunteers in the study. Unexpectedly, only about 60% of screened participants from the hospital and GP sources were randomized and 33.2% from health care services. Almost a quarter of the randomized participants come from the hospital outpatients clinics and approximately 20% from public conferences. A total of 1128 contacts yielded to 556 screened volunteers and 345 randomized participants in the coordinating center of Toulouse. Thus, 30 % of contacts were recruited.

Indexed as

Patient SelectionAgedAlzheimer DiseaseDouble-Blind MethodFatty Acids, Omega-3Focus GroupsHumansPatient ComplianceRandomized Controlled Trials as TopicResearch DesignFatty Acids, Omega-3

Identifiers

PMID22499458
PMCPMC12878063

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.