Evidence map›Paper›PMID 22499139›Full record

ArticleKidney international2012

Can we cure HIV-1-associated nephropathy in transgenic mice?

Patricio E Ray

Open access · greenAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Patricio E RayCenter for Molecular Physiology Research, The George Washington University, Washington, DC, USA. Pray@cnmc.org
Children's National · US

Funding

Role of bFGF low affinity receptors in childhood HIVANR01DK049419 · NIDDK · UNIVERSITY OF VIRGINIA · PI PATRICIO E. RAY · 1994 to 2026
$7.4M
Pathogenesis of HIV-HUS in childrenR01HL055605 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI RAY, PATRICIO E. · 1995 to 2012
$4.3M
Role of heparin binding growth factors in vascular leakage and fatal bleedingR01HL102497 · NHLBI · UNIVERSITY OF VIRGINIA · PI RAY, PATRICIO E. · 2009 to 2018
$3.4M
NHLBI NIH HHS R01 HL055605NHLBI NIH HHS R01 HL102497NHLBI NIH HHS R01-HL-102497NHLBI NIH HHS R01-HL55605NIDDK NIH HHS R01 DK049419NIDDK NIH HHS R01-DK049419
6 · The paper itself

Abstract

HIV-1-associated nephropathy (HIVAN) is a rapidly progressive form of focal segmental glomerulosclerosis. HIV transgenic mice can develop a HIVAN-like renal disease. Zhong et al. show that the oral administration of a cyclic nucleotide phosphodiesterase 4 inhibitor and a retinoic acid receptor-α agonist can prevent the development of HIVAN in transgenic mice, acting through a cAMP-dependent mechanism that is independent of HIV-1 genes. These findings suggest that endogenous host factors play a critical role in HIVAN.

Indexed as

AIDS-Associated NephropathyAminopyridinesAnimalsBenzamidesBenzoatesCyclopropanesFemaleHIV-1HIV InfectionsKidney TubulesMalePhosphodiesterase 4 InhibitorsRenal InsufficiencyTetrahydronaphthalenesAm 580AminopyridinesBenzamidesBenzoatesCyclopropanesPhosphodiesterase 4 InhibitorsRoflumilastTetrahydronaphthalenes

Identifiers

PMID22499139
PMCPMC3334344
OpenAlexW2062954477

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.