Evidence map›Paper›PMID 22499036›Full record

ArticleThe Journal of investigative dermatology2012

Building models for keratin disorders.

Maranke I Koster

Abstract readComment
PubMed Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Gene expression profiling in pachyonychia congenita skin.Journal of dermatological science · 2015
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Maranke I KosterDepartment of Dermatology, Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology, University of Colorado, Aurora, Colorado 80045, USA. Maranke.Koster@ucdenver.edu

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Palmoplantar keratoderma is a hallmark of pachyonychia congenita (PC) and focal non-epidermolytic palmoplantar keratoderma (FNEPPK). By generating keratin 16 (Krt16)-deficient mice, Lessard and Coulombe, as described in this issue, have generated a mouse model to replicate these palmoplantar lesions. Studies using this model may provide novel insights into the molecular mechanisms responsible for the formation of palmoplantar lesions in PC and FNEPPK patients.

Indexed as

AnimalsFemaleKeratin-16Keratoderma, PalmoplantarMaleRNA, MessengerTongueKeratin-16RNA, Messenger

Identifiers

PMID22499036

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.