ArticleJournal of medical virology2012
Broad respiratory virus detection in infants hospitalized for bronchiolitis by use of a multiplex RT-PCR DNA microarray system.
Article in Journal of medical virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 5 of them syntheses that pooled it.
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The trial behind it
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Who cites it
44 citing papers in PubMed, 5 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Investigations for Bronchiolitis in Infants: An Overview of Reviews and Systematic Review of Primary Studies.Pediatric pulmonology · 2026Pooled it
- Pooled it
- Multiplex PCR system for the rapid diagnosis of respiratory virus infection: systematic review and meta-analysis.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2018Pooled it
- Respiratory viral coinfection and disease severity in children: A systematic review and meta-analysis.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2016Pooled it
- Single and multiple respiratory virus infections and severity of respiratory disease: a systematic review.Paediatric respiratory reviews · 2014Pooled it
- Article
- Epidemiological profile of respiratory viruses associated with influenza-like illness and severe acute respiratory infection in Guangzhou, China, 2024-2025.Frontiers in public health · 2026Article
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- Genomic surveillance and evolutionary dynamics of respiratory syncytial virus circulating in Tunisia post-COVID-19 pandemic lockdown restrictions.IJID regions · 2025Article
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- Respiratory Viral Coinfections: Insights into Epidemiology, Immune Response, Pathology, and Clinical Outcomes.Pathogens (Basel, Switzerland) · 2024Review
- Use of Rapid Antigen Triple Test Nasal Swabs (COVID-VIRO ALL-IN TRIPLEX: Severe Acute Respiratory Syndrome Coronavirus 2, Respiratory Syncytial Virus, and Influenza) in Children With Respiratory Symptoms: A Real-life Prospective Study.Open forum infectious diseases · 2024Article
- Outcomes of viral coinfections in infants hospitalized for acute bronchiolitis.Virology journal · 2023Observational
- Antibody Phage Display Technology for Sensor-Based Virus Detection: Current Status and Future Prospects.Biosensors · 2023Review
- Acute Viral Bronchiolitis: A Narrative Review.Journal of pediatric intensive care · 2023Review
- The role of the surface ligand on the performance of electrochemical SARS-CoV-2 antigen biosensors.Analytical and bioanalytical chemistry · 2022Review
- Micro/nanotechnology-inspired rapid diagnosis of respiratory infectious diseases.Biomedical engineering letters · 2021Review
- Human bocavirus-1 screening in infants with acute lower respiratory tract infection.The Journal of international medical research · 2021Article
- Acoustical Slot Mode Sensor for the Rapid Coronaviruses Detection.Sensors (Basel, Switzerland) · 2021Article
- Microfluidic-based approaches for COVID-19 diagnosis.Biomicrofluidics · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Newly available molecular tools allow a sensitive detection of a broad panel of viruses in respiratory tract specimens. In the present study, the application of a multiplex RT-PCR DNA microarray in diagnosis and epidemiological survey of viral infections in infants hospitalized for bronchiolitis was assessed. One hundred and thirty-eight nasopharyngeal aspirates collected from October 2007 to September 2008 were tested by direct immunofluorescence and viral culture, a combination of referenced RT-PCRs and the DNA microarray. One or more viruses were detected in 96, 126 and 126 of the specimens by direct immunofluorescence and viral culture, RT-PCRs and DNA microarray, respectively (70 vs. 91 vs. 91%, P < 10(-3)). The RT-PCRs and the DNA microarray yielded concordant results for 99% of specimens and identified mixed viral infections in 85 (62%). The most common associations were: human bocavirus and respiratory syncytial virus (32%), adenovirus and respiratory syncytial virus (30%), and parainfluenza virus type 3 and respiratory syncytial virus (23%). None of the bronchiolitis severity parameters including intensive care unit admission, O(2) supply, O(2) saturation percentage, O(2) length and length of stay at the hospital appeared to be significantly increased in multiple viral infections compared to single viral infections (P > 0.1). In conclusion, the use of this DNA microarray in clinical virology practice allows rapid and accurate identification of common and uncommon viral respiratory pathogens in infants hospitalized for bronchiolitis. It should improve the clinical management, the epidemiological survey, and the prevention of the nosocomial transmission of respiratory viruses in pediatric wards.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.