Evidence map›Paper›PMID 22498958›Full record

ReviewChemical Society reviews2012

Mass spectrometry-based proteomics: existing capabilities and future directions.

Thomas E Angel, Uma K Aryal, Shawna M Hengel, Erin S Baker, Ryan T Kelly, Errol W Robinson, Richard D Smith

Abstract readReview
In one paragraph

Review in Chemical Society reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 151 papers.

0numbers the graph read from it
0cells of the map it votes in
151citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

151 citing papers in PubMed.

  1. Article
  2. Review
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  14. Article
  15. Posttranslational Modifications in Proteins Under Stress and Memory.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  16. Review
  17. Mass Spectrometry for Proteomics-Based Investigation.Advances in experimental medicine and biology · 2026
    Review
  18. Review
  19. Article
  20. Article

91 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Thomas E AngelBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA.
Uma K Aryal
Shawna M Hengel
Erin S Baker
Ryan T Kelly
Errol W Robinson
Richard D Smith

Funding

WORKSHOP AND TRAINING ACTIVITIESP41RR018522 · NCRR · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI SMITH, RICHARD D · 2003 to 2011
$25.1M
Equipment Supplement Request for a Research Resource for Ultra-sensitive High Throughput ProteomicsP41GM103493 · NIGMS · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI SMITH, RICHARD D · 2012 to 2022
$22.6M
PNNL Clinical Proteome Characterization CenterU24CA160019 · NCI · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI RODLAND, KARIN D, SMITH, RICHARD D · 2011 to 2016
$15.7M
NCI NIH HHS U24 CA160019NCI NIH HHS U24-CA-160019-01NCRR NIH HHS 5P41RR018522-10NCRR NIH HHS P41 RR018522NIGMS NIH HHS 8 P41 GM103493-10NIGMS NIH HHS P41 GM103493
6 · The paper itself

Abstract

Mass spectrometry (MS)-based proteomics is emerging as a broadly effective means for identification, characterization, and quantification of proteins that are integral components of the processes essential for life. Characterization of proteins at the proteome and sub-proteome (e.g., the phosphoproteome, proteoglycome, or degradome/peptidome) levels provides a foundation for understanding fundamental aspects of biology. Emerging technologies such as ion mobility separations coupled with MS and microchip-based-proteome measurements combined with MS instrumentation and chromatographic separation techniques, such as nanoscale reversed phase liquid chromatography and capillary electrophoresis, show great promise for both broad undirected and targeted highly sensitive measurements. MS-based proteomics increasingly contribute to our understanding of the dynamics, interactions, and roles that proteins and peptides play, advancing our understanding of biology on a systems wide level for a wide range of applications including investigations of microbial communities, bioremediation, and human health.

Indexed as

AnimalsChromatography, LiquidHumansMass SpectrometryProtein Processing, Post-TranslationalProteomeProteomicsProteome

Identifiers

PMID22498958
PMCPMC3375054

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.