ArticleImmunogenetics1990
Experimental allergic orchitis in mice. VI. Recombinations within the H-2S/H-2D interval define the map position of the H-2-associated locus controlling disease susceptibility.
Article in Immunogenetics, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Identification of Orch3, a locus controlling dominant resistance to autoimmune orchitis, as kinesin family member 1C.PLoS genetics · 2012Article
- Autoimmune orchitis, epididymitis, and vasitis are immunogenetically distinct lesions.The American journal of pathology · 1998Article
- A detailed physical map of the porcine major histocompatibility complex (MHC) class III region: comparison with human and mouse MHC class III regions.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- Multiple loci govern the bone marrow-derived immunoregulatory mechanism controlling dominant resistance to autoimmune orchitis.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- A susceptibility gene for alveolar lung tumors in the mouse maps between Hsp70.3 and G7 within the H2 complex.Immunogenetics · 1995Article
- New microsatellite size variants as markers for a cross-over hotspot in the C4-H-2D region.Mammalian genome : official journal of the International Mammalian Genome Society · 1994Article
- Coding sequences and levels of expression of Hsc70t are identical in mice with different Orch-1 alleles.Immunogenetics · 1994Article
- P1 and cosmid clones define the organization of 280 kb of the mouse H-2 complex containing the Cps-1 and Hsp70 loci.Immunogenetics · 1994Article
- RFLP analysis of the MHC class III region defines unique haplotypes for the non-obese diabetic, cataract Shionogi and the non-obese non-diabetic mouse strains.Diabetologia · 1993Article
- Localization of a new gene adjacent to the HSP70 genes in human and mouse MHCs.Immunogenetics · 1993Article
- Meiotic recombination within the H-2K-H-2D interval: characterization of a panel of congenic mice, including 12 new strains, using DNA markers.Immunogenetics · 1993Article
- Testis-/embryo-expressed genes are clustered in the mouse H-2K region.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Polymorphic analysis of the three MHC-linked HSP70 genes.Immunogenetics · 1992Article
- PFGE mapping and RFLP analysis of the S/D region of the mouse H-2 complex.Immunogenetics · 1992Article
- Mouse chromosome 17.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Review
- Fine mapping of the crossover-sites in the C4-H-2D region of H-2 recombinant mouse strains.Immunogenetics · 1991Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Susceptibility to autoimmune orchitis is associated with an immune response (Ir) gene (now designated Orch-1) which was preliminarily shown to reside at or near the H-2D subregion of the major histocompatibility complex in the mouse (H-2). In this study, the role of H-2 in controlling both disease susceptibility and the phenotypic expression of infertility associated with autoimmune orchitis has been significantly extended. Of nine C57BL/10SnJ and three BALB/cAnN H-2 congenic strains, only those mice possessing the H-2d, H-2p haplotypes exhibited autoimmune orchitis accompanied by infertility. All other congenic strains, including those expressing the H-2 haplotypes v, q, b, s, r, f, and k were of the low responder phenotype. In addition, disease susceptibility was found to be inherited as a dominant trait in H-2 congenic F1 hybrid mice. In order to map the precise location of the Orch-1 locus within H-2, 32 intra-H-2 recombinant congenic strains possessing defined crossovers in various locations throughout the H-2 region were studied. The results of the analysis indicate that Orch-1 maps within the interval between the H-2S and H-2D regions. Our results also indicate that class II genes, i.e., A and E region-encoded genes, have little discernable effect in controlling disease susceptibility and resistance despite the fact that testicular lesions can be adoptively transferred with Ia-restricted CD4+ effector T cells. A comparison of the Orch-1 alleles with the genotypes of two additional markers which map within the H-2S/H-2D interval suggests the following gene order: H-2S--TNP-Ficoll--Orch-1--Tnfa--H-2D.
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