ReviewBest practice & research. Clinical endocrinology & metabolism2012
Is genetic testing useful to predict type 2 diabetes?
Review in Best practice & research. Clinical endocrinology & metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 59 citations in OpenAlex.
- The effect of genetic counseling for adult offspring of patients with type 2 diabetes on attitudes toward diabetes and its heredity: a randomized controlled trial.Journal of genetic counseling · 2014Trial
- The development of type 2 diabetes amongst sibling pairs in the South-South region of Nigeria: The effect of genetics, environment and lifestyle.Diabetic medicine : a journal of the British Diabetic Association · 2026Article
- Operon™ Platform-Enabled for Cardiometabolic Biomarker Screening and Precision Treatment Strategies: A Type 2 Diabetes-Centered Review with Cardiovascular Extension.International journal of molecular sciences · 2026Review
- Lean type 2 diabetes: the overlooked epidemic reshaping global health.Diabetology & metabolic syndrome · 2025Review
- Type 2 Diabetes Subtyping via Phenotype and Genotype Co-Learning.Studies in health technology and informatics · 2025Article
- Circular RNAs and the regulation of gene expression in diabetic nephropathy (Review).International journal of molecular medicine · 2024Article
- TCF7L2 and FTO Polymorphisms Are Associated with Type 2 Diabetes Mellitus Risk in Kuwait.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2024Article
- The Glycemic Curve during the Oral Glucose Tolerance Test: Is It Only Indicative of Glycoregulation?Biomedicines · 2023Article
- Early Prediction for Prediabetes and Type 2 Diabetes Using the Genetic Risk Score and Oxidative Stress Score.Antioxidants (Basel, Switzerland) · 2022Article
- Exome Chip Analysis of 14,026 Koreans Reveals Known and Newly Discovered Genetic Loci Associated with Type 2 Diabetes Mellitus.Diabetes & metabolism journal · 2021Article
- Recent advances and perspectives in next generation sequencing application to the genetic research of type 2 diabetes.World journal of diabetes · 2019Review
- Racialized Risk in Clinical Care: Clinician Vigilance and Patient Responsibility.Medical anthropology · 2019Article
- Human Genetics of Obesity and Type 2 Diabetes Mellitus: Past, Present, and Future.Circulation. Genomic and precision medicine · 2018Review
- Genetic risk score of common genetic variants for impaired fasting glucose and newly diagnosed type 2 diabetes influences oxidative stress.Scientific reports · 2018Article
- Enrichment of minor allele of SNPs and genetic prediction of type 2 diabetes risk in British population.PloS one · 2017Article
- Genetic-risk assessment of GWAS-derived susceptibility loci for type 2 diabetes in a 10 year follow-up of a population-based cohort study.Journal of human genetics · 2016Article
- Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes.Nature communications · 2016Article
- Improved prediction of complex diseases by common genetic markers: state of the art and further perspectives.Human genetics · 2016Review
- Utilizing Genetic Predisposition Score in Predicting Risk of Type 2 Diabetes Mellitus Incidence: A Community-based Cohort Study on Middle-aged Koreans.Journal of Korean medical science · 2015Article
- Genome-Wide Association Identifies SLC2A9 and NLN Gene Regions as Associated with Entropion in Domestic Sheep.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The early identification of individuals at risk for type 2 diabetes (T2D) enables prevention. Recent genome-wide association studies (GWAS) have added at least 40 genetic variants to the list of already well characterized T2D risk predictors, including family history, obesity, and elevated fasting plasma glucose levels. Although these variants can significantly predict T2D alone and as a part of genotype risk scores, they do not yet offer clinical discrimination beyond that achieved with common clinical measurements. Future progress on at least two research fronts may improve the predictive performance of genotype information. First, expanded GWAS efforts in non-European populations will allow targeted sequencing of risk loci and the identification of true causal variants. Second, studies with longer prediction time horizons may demonstrate that genotype information performs better than clinical risk predictors over a longer period of the life course. At present, however, genetic testing cannot be recommended for clinical T2D risk prediction in adults.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.