ArticleExperimental neurology2012
The roles of neuronal and glial precursors in overcoming chondroitin sulfate proteoglycan inhibition.
Article in Experimental neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 44 citations in OpenAlex.
- Clickable Granular Hydrogel Scaffolds for Delivery of Neural Progenitor Cells to Sites of Spinal Cord Injury.Advanced healthcare materials · 2024Article
- Article
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- Transplanting neural progenitor cells to restore connectivity after spinal cord injury.Nature reviews. Neuroscience · 2020Review
- Transplanting Cells for Spinal Cord Repair: Who, What, When, Where and Why?Cell transplantation · 2019Article
- Diverse functions of protein tyrosine phosphatase σ in the nervous and immune systems.Experimental neurology · 2018Review
- Chondroitin sulfate proteoglycans negatively regulate the positioning of mitochondria and endoplasmic reticulum to distal axons.Developmental neurobiology · 2017Article
- Rewiring the spinal cord: Direct and indirect strategies.Neuroscience letters · 2017Review
- Improving the therapeutic efficacy of neural progenitor cell transplantation following spinal cord injury.Expert review of neurotherapeutics · 2017Review
- Examining the properties and therapeutic potential of glial restricted precursors in spinal cord injury.Neural regeneration research · 2016Review
- Guiding migration of transplanted glial progenitor cells in the injured spinal cord.Scientific reports · 2016Article
- Glial restricted precursors maintain their permissive properties after long-term expansion but not following exposure to pro-inflammatory factors.Brain research · 2015Article
- Repair of spinal cord injury with neuronal relays: From fetal grafts to neural stem cells.Brain research · 2015Review
- Molecular mechanisms of scar-sourced axon growth inhibitors.Brain research · 2015Review
- The Neural Stem Cell Microenvironment: Focusing on Axon Guidance Molecules and Myelin-Associated Factors.Journal of molecular neuroscience : MN · 2015Review
- Cell adhesion properties of neural stem cells in the chick embryo.In vitro cellular & developmental biology. Animal · 2015Article
- NG2+ progenitors derived from embryonic stem cells penetrate glial scar and promote axonal outgrowth into white matter after spinal cord injury.Stem cells translational medicine · 2015Article
- Astrocytes alignment and reactivity on collagen hydrogels patterned with ECM proteins.Biomaterials · 2015Article
- Protein tyrosine phosphatase-σ regulates hematopoietic stem cell-repopulating capacity.The Journal of clinical investigation · 2015Article
- Activation of PI3K and R-Ras signaling promotes the extension of sensory axons on inhibitory chondroitin sulfate proteoglycans.Developmental neurobiology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The extension of axons through the major inhibitory component of the glial scar, chondroitin sulfate proteoglycans (CSPGs), remains a key obstacle for regeneration following spinal cord injury (SCI). We have previously shown that transplants composed of neuronal and glial restricted precursors (NRP and GRP respectively) promote regeneration and connectivity in the injured spinal cord (Bonner et al., 2010, 2011), however, little is known about the properties of these precursors at a cellular level. We now report that NRP-derived neurons, in contrast to dorsal root ganglion (DRG) neurons, have the ability to extend axons and cross over from a permissive substratum (laminin) onto inhibitory CSPG in vitro. Growth cones of neurons derived from NRP, compared to DRG, exhibit significantly lower levels of the CSPG receptors protein tyrosine phosphatase sigma (PTPσ) and leukocyte common antigen-related phosphatase (LAR). GRP-conditioned medium prepared from the same cell densities did not affect the response of primary sensory neurons to CSPG confirming that the ability of NRP-derived neurons to cross onto CSPG is determined intrinsically. However, GRP-conditioned medium collected from high density cultures increased the probability of DRG axons to cross from LN onto CSPG and increased the length of DRG axons extending on CSPG. Collectively, these results suggest that (1) neurons derived from NRPs are intrinsically insensitive to CSPGs due to low levels of receptor expression, and (2) high levels of factors secreted by GRP can reduce the inhibitory effects of CSPG and promote axonal growth. These observations provide mechanistic insights into the specific roles of NRPs and GRPs in promoting regeneration and repair following SCI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.