ArticleJournal of psychiatry & neuroscience : JPN2012
Schizophrenia with preserved insight is associated with increased perfusion of the precuneus.
Article in Journal of psychiatry & neuroscience : JPN, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review reveals heterogeneity in the use of the Scale to Assess Unawareness of Mental Disorder (SUMD).Current psychiatry reports · 2013Pooled it
- Effects of NMDA-receptor blockade by ketamine on mentalizing and its neural correlates in humans: a randomized control trial.Scientific reports · 2023Trial
- Assessment of resting cerebral perfusion between methamphetamine-associated psychosis and schizophrenia through arterial spin labeling MRI.European archives of psychiatry and clinical neuroscience · 2025Article
- Impaired insight in schizophrenia is associated with higher frontoparietal cerebral blood flow: an arterial spin labeling study.Schizophrenia (Heidelberg, Germany) · 2025Article
- Abnormal arteriolar blood volume measured by 3D inflow-based vascular-space-occupancy (iVASO) MRI and resting-state BOLD fluctuations at 7 T in individuals with recent-onset schizophrenia.Psychoradiology · 2025Article
- Clinical anatomy of the precuneus and pathogenesis of the schizophrenia.Anatomical science international · 2023Review
- Controllability of Functional Brain Networks and Its Clinical Significance in First-Episode Schizophrenia.Schizophrenia bulletin · 2023Article
- Impaired large-scale cortico-hippocampal network connectivity, including the anterior temporal and posterior medial systems, and its associations with cognition in patients with first-episode schizophrenia.Frontiers in neuroscience · 2023Article
- Brain structural correlates of schizotypal signs and subclinical schizophrenia nuclear symptoms in healthy individuals.Psychological medicine · 2022Article
- Mapping Brain Microstructure and Network Alterations in Depressive Patients with Suicide Attempts Using Generalized Q-Sampling MRI.Journal of personalized medicine · 2021Article
- Impaired illness awareness in schizophrenia and posterior corpus callosal white matter tract integrity.NPJ schizophrenia · 2019Article
- Hybrid Functional Brain Network With First-Order and Second-Order Information for Computer-Aided Diagnosis of Schizophrenia.Frontiers in neuroscience · 2019Article
- Self-perception of mental illness, and subjective and objective cognitive functioning in people with schizophrenia.Neuropsychiatric disease and treatment · 2019Article
- Effects of DISC1 Polymorphisms on Resting-State Spontaneous Neuronal Activity in the Early-Stage of Schizophrenia.Frontiers in psychiatry · 2018Article
- Classification of multi-site MR images in the presence of heterogeneity using multi-task learning.NeuroImage. Clinical · 2018Article
- Abnormal Grey Matter Arteriolar Cerebral Blood Volume in Schizophrenia Measured With 3D Inflow-Based Vascular-Space-Occupancy MRI at 7T.Schizophrenia bulletin · 2017Article
- The metabolic basis of cognitive insight in psychosis: A positron emission tomography study.PloS one · 2017Article
- Altered regional homogeneity in patients with unilateral acute open-globe injury: a resting-state functional MRI study.Neuropsychiatric disease and treatment · 2016Article
- Alterations in hippocampal connectivity across the psychosis dimension.Psychiatry research · 2015Article
- Neurobiology of insight deficits in schizophrenia: An fMRI study.Schizophrenia research · 2015Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPreserved insight into illness has been suggested to be predictive of outcome in patients with schizophrenia. We aimed to investigate the functional substrate underlying preserved insight in these patients.
methodsWe recruited patients with paranoid schizophrenia and healthy controls matched for age and sex. Patients were grouped according to preserved or impaired insight into illness using the Scale to assess Unawareness of Mental Disorder (SUMD). Whole-brain technetium-99m ethyl cysteinate dimer single photon emission computed tomography regional cerebral blood flow was compared at the voxel level between the 2 groups using a statistical parametric map (voxel-level significance of p < 0.001, uncorrected; cluster level significance of p < 0.05, uncorrected).
resultsWe enrolled 31 right-handed patients with schizophrenia and 18 controls in our study. Twenty-one (67.7%) patients had preserved insight. The 2 groups did not differ significantly in demographic and clinical characteristics or in treatment. Compared with controls, the whole group of patients showed bilateral frontotemporal hypoperfusions, with no statistical difference between patients with preserved or impaired insight for these areas. Patients with preserved insight showed significantly increased perfusion of the bilateral precuneus relative to those with impaired insight. LIMITATIONS: Patients with subtypes other than paranoid schizophrenia have to be investigated to assess whether involvement of the precuneus in patients with preserved insight can be identified across the full spectrum of subtypes and symptoms of schizophrenia. Moreover, our study concerned only the central dimension (awareness of mental disorder) of 1 scale (SUMD); other dimensions of insight could be studied.
conclusionOur results show that schizophrenia with preserved insight is associated with greater perfusion of the precuneus, a brain area known to be involved in self- consciousness, suggesting a compensatory mechanism of fronto-temporal impairment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.