Evidence map›Paper›PMID 22497940›Full record

ArticleCurrent biology : CB2012

Chromosomal Instability: Mad2 beyond the spindle checkpoint.

Edward R Ballister, Michael A Lampson

Abstract readComment
PubMed Publisher
In one paragraph

Article in Current biology : CB, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Edward R BallisterGraduate Group in Biochemistry and Molecular Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Michael A Lampson

Funding

Regulation of cell division by mitotic kinasesR01GM083988 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI GRISHCHUK, EKATERINA L, LAMPSON, MICHAEL · 2008 to 2017
$3.2M
NIGMS NIH HHS R01 GM083988
6 · The paper itself

Abstract

What specific defects can cause chromosomal instability in cancer cells? Overexpression of the mitotic checkpoint protein Mad2 triggers chromosome missegregation but, surprisingly, Mad2 exerts this effect through a previously unknown effect on microtubule dynamics.

Indexed as

Chromosome SegregationCalcium-Binding ProteinsCell Cycle ProteinsKinetochoresMad2 ProteinsMicrotubulesRepressor ProteinsCalcium-Binding ProteinsCell Cycle ProteinsMAD2L1 protein, humanMad2 ProteinsRepressor Proteins

Identifiers

PMID22497940

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.