ArticleAnnals of human genetics2012
Effect of population stratification on false positive rates of population-based association analyses of quantitative traits.
Article in Annals of human genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Genome-wide association study identifies novel and confirms established loci associated with serum lipids levels in Brazilians.Human genetics · 2026Article
- A transcription factor gene CaMYB114 associated with black seed coat in chickpea.BMC plant biology · 2025Article
- Identification of MAPK10 as a Candidate Gene for High Milk Production in Water Buffaloes Through a Genome-Wide Association Study.Animals : an open access journal from MDPI · 2025Article
- Improved detection of microbiome-disease associations via population structure-aware generalized linear mixed effects models (microSLAM).PLoS computational biology · 2025Article
- Article
- Article
- Genome-wide association study on dairy goat milk production traits using three models.Frontiers in genetics · 2025Article
- Identification of Candidate Genes and Functional Pathways Associated with Body Size Traits in Chinese Holstein Cattle Based on GWAS Analysis.Animals : an open access journal from MDPI · 2023Article
- Article
- Genome-Wide Association Study for Udder Conformation Traits in Chinese Holstein Cattle.Animals : an open access journal from MDPI · 2022Article
- Trade-offs of Linear Mixed Models in Genome-Wide Association Studies.Journal of computational biology : a journal of computational molecular cell biology · 2022Article
- Genome-wide association studies for immunoglobulin concentrations in colostrum and serum in Chinese Holstein.BMC genomics · 2022Article
- Article
- Genome-Wide Association Study Identifies Candidate Genes Associated with Feet and Leg Conformation Traits in Chinese Holstein Cattle.Animals : an open access journal from MDPI · 2021Article
- Variant-specific inflation factors for assessing population stratification at the phenotypic variance level.Nature communications · 2021Article
- Genome-Wide Association Studies for the Concentration of Albumin in Colostrum and Serum in Chinese Holstein.Animals : an open access journal from MDPI · 2020Article
- Genetics of Smoking Behaviors in American Indians.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- A Cautionary Note on the Effects of Population Stratification Under an Extreme Phenotype Sampling Design.Frontiers in genetics · 2019Article
- Genome-wide association study of Mycobacterium avium subspecies Paratuberculosis infection in Chinese Holstein.BMC genomics · 2018Article
- Association of macrophage migration inhibitory factor promoter polymorphism -173G/C with susceptibility to childhood asthma.Central-European journal of immunology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
It is now well established that population stratification can result in spurious association findings in genetic case-control studies. However, very few studies have addressed similar issues for mapping quantitative traits. Because quantitative phenotypes are often precursors of clinical endpoint traits and carry more information on within-genotype trait variability, it has been argued that studying these quantitative traits may be a more powerful strategy to map genes than the binary clinical endpoints. Thus, it is of interest to evaluate the adverse effects of population stratification on the analyses of quantitative traits. The popular statistical tests of association for quantitative traits using population level data are ANOVA, linear regression with an additive allelic effect and Kruskal-Wallis. We have theoretically studied the marginal effects of genetic heterogeneity and phenotypic heterogeneity as well as their joint effects on the false positive rates of these three tests. We have carried out extensive simulations under different genetic models and probability distributions of quantitative traits to assess the rate of false positives in the presence of population stratification. We find that the rate of false positives increases very quickly with simultaneous increase in differences in the standardized phenotypic means and marker allele frequencies in the subpopulations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.