Evidence map›Paper›PMID 22497282›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2012

Plasma lipid metabolites are associated with gestational age but not bronchopulmonary dysplasia.

Lynette K Rogers, Christine M Young, Michael L Pennell, Trent E Tipple, Karen L Leonhart, Stephen E Welty

Open access · greenAbstract read
In one paragraph

Article in Acta paediatrica (Oslo, Norway : 1992), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Attenuation of miR-17∼92 Cluster in Bronchopulmonary Dysplasia.Annals of the American Thoracic Society · 2015
    Article
  6. DHA suppresses chronic apoptosis in the lung caused by perinatal inflammation.American journal of physiology. Lung cellular and molecular physiology · 2015
    Article
  7. Cyclooxygenase-2 in newborn hyperoxic lung injury.Free radical biology & medicine · 2013
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Lynette K RogersDepartment of Pediatrics, Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA. lynette.rogers@nationwidechildrens.org
Christine M Young
Michael L Pennell
Trent E Tipple
Karen L Leonhart
Stephen E Welty
The Ohio State University · USBaylor College of Medicine · USNationwide Children's Hospital · US

Funding

The Ohio State University Center for Clinical and Translational Science (UL1)UL1TR000090 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2012 to 2013
$7.9M
DHA attenuates Inflammatory Responses Through Altering RAGE SignalingR01AT006880 · NCCIH · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI ROGERS, LYNETTE KAY · 2011 to 2015
$1.8M
Regulation of Lung Growth and Development by Thioredoxin Interacting ProteinK08HL093365 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI TIPPLE, TRENT · 2010 to 2012
$399k
NCATS NIH HHS UL1 TR000090NCCIH NIH HHS R01 AT006880NHLBI NIH HHS K08 HL093365
6 · The paper itself

Abstract

aimTo test the hypothesis that plasma lipid metabolite levels in premature infants are associated with the development of bronchopulmonary dysplasia (BPD). The studies also tested a secondary hypothesis that plasma lipid metabolite levels were correlated with gestational age.

methodsInfants born <32 weeks' gestation were enrolled during the first 72 h of life. Plasma samples were obtained and lipid levels were measured by LC-MS/MS. Clinical data were collected to determine infant outcomes and BPD diagnosis.

resultsFollowing adjustment for confounders, lipid levels were not associated with BPD; however, levels of specific lipid metabolites were correlated with gestational age.

conclusionImmature lipid metabolism pathways in premature infants may contribute to the pathogenesis of BPD and other diseases.

Indexed as

Gestational AgeBronchopulmonary DysplasiaChromatography, LiquidFatty Acids, UnsaturatedFemaleHumansInfant, NewbornInfant, PrematureLinear ModelsLogistic ModelsMaleProspective StudiesTandem Mass SpectrometryFatty Acids, Unsaturated

Identifiers

PMID22497282
PMCPMC3693574
OpenAlexW1899665244

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.