ArticlePloS one2012
Dose-response aligned circuits in signaling systems.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Article
- Design principles of improving the dose-response alignment in coupled GTPase switches.NPJ systems biology and applications · 2023Article
- The Topological Characteristics of Biological Ratio-Sensing Networks.Life (Basel, Switzerland) · 2023Article
- Molecular switch architecture determines response properties of signaling pathways.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Constructing network topologies for multiple signal-encoding functions.BMC systems biology · 2019Article
- Experimental and engineering approaches to intracellular communication.Essays in biochemistry · 2018Review
- Robust network topologies for generating oscillations with temperature-independent periods.PloS one · 2017Article
- Identifying ultrasensitive HGF dose-response functions in a 3D mammalian system for synthetic morphogenesis.Scientific reports · 2016Article
- Push-Pull and Feedback Mechanisms Can Align Signaling System Outputs with Inputs.Cell systems · 2016Article
- Using Sub-Network Combinations to Scale Up an Enumeration Method for Determining the Network Structures of Biological Functions.PloS one · 2016Article
- Non-monotonic dynamics and crosstalk in signaling pathways and their implications for pharmacology.Scientific reports · 2015Article
- From Boolean Network Model to Continuous Model Helps in Design of Functional Circuits.PloS one · 2015Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cells use biological signal transduction pathways to respond to environmental stimuli and the behavior of many cell types depends on precise sensing and transmission of external information. A notable property of signal transduction that was characterized in the Saccharomyces cerevisiae yeast cell and many mammalian cells is the alignment of dose-response curves. It was found that the dose response of the receptor matches closely the dose responses of the downstream. This dose-response alignment (DoRA) renders equal sensitivities and concordant responses in different parts of signaling system and guarantees a faithful information transmission. The experimental observations raise interesting questions about the nature of the information transmission through DoRA signaling networks and design principles of signaling systems with this function. Here, we performed an exhaustive computational analysis on network architectures that underlie the DoRA function in simple regulatory networks composed of two and three enzymes. The minimal circuits capable of DoRA were examined with Michaelis-Menten kinetics. Several motifs that are essential for the dynamical function of DoRA were identified. Systematic analysis of the topology space of robust DoRA circuits revealed that, rather than fine-tuning the network's parameters, the function is primarily realized by enzymatic regulations on the controlled node that are constrained in limiting regions of saturation or linearity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.