ArticlePloS one2012
A full suite of histone and histone modifying genes are transcribed in the dinoflagellate Lingulodinium.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 60 citations in OpenAlex.
- Nucleosome Assembly Protein 1 in Dinoflagellate Cells Without Architectural Nucleosomes.International journal of molecular sciences · 2026Article
- Effect of cellular nutrient economy on the evolution of genome size in phytoplankton.Science advances · 2026Article
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- Unraveling a Receptor-Mediated Bioluminescence Signaling Pathway in Red Tide Algae.Journal of molecular biology · 2025Article
- Dinochromosome Heterotermini with Telosomal Anchorages.International journal of molecular sciences · 2024Article
- Review
- The enigmatic nucleus of the marine dinoflagellatemSphere · 2023Article
- Upregulation of Peridinin-Chlorophyll A-Binding Protein in a Toxic Strain ofInternational journal of molecular sciences · 2023Article
- Chromatin Unlimited: An Evolutionary View of Chromatin.Epigenomes · 2022Article
- The enigmatic clock of dinoflagellates, is it unique?Frontiers in microbiology · 2022Review
- The tropical coralWellcome open research · 2021Article
- Biosynthesis of Saxitoxin in Marine Dinoflagellates: An Omics Perspective.Marine drugs · 2020Review
- Assessing Transcriptional Responses to Light by the DinoflagellateMicroorganisms · 2019Article
- The Biochemistry and Evolution of the Dinoflagellate Nucleus.Microorganisms · 2019Review
- The Genetic Basis of Toxin Biosynthesis in Dinoflagellates.Microorganisms · 2019Review
- Chromosomal markers in the genus Karenia: Towards an understanding of the evolution of the chromosomes, life cycle patterns and phylogenetic relationships in dinoflagellates.Scientific reports · 2019Article
- Distinctive Nuclear Features of Dinoflagellates with A Particular Focus on Histone and Histone-Replacement Proteins.Microorganisms · 2018Review
- Viral proteins as a potential driver of histone depletion in dinoflagellates.Nature communications · 2018Article
- Translation and Translational Control in Dinoflagellates.Microorganisms · 2018Review
- A proteomic portrait of dinoflagellate chromatin reveals abundant RNA-binding proteins.Chromosoma · 2018Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDinoflagellates typically lack histones and nucleosomes are not observed in DNA spreads. However, recent studies have shown the presence of core histone mRNA sequences scattered among different dinoflagellate species. To date, the presence of all components required for manufacturing and modifying nucleosomes in a single dinoflagellate species has not been confirmed. METHODOLOGY AND
resultsAnalysis of a Lingulodinium transcriptome obtained by Illumina sequencing of mRNA shows several different copies of each of the four core histones as well as a suite of histone modifying enzymes and histone chaperone proteins. Phylogenetic analysis shows one of each Lingulodinium histone copies belongs to the dinoflagellate clade while the second is more divergent and does not share a common ancestor. All histone mRNAs are in low abundance (roughly 25 times lower than higher plants) and transcript levels do not vary over the cell cycle. We also tested Lingulodinium extracts for histone proteins using immunoblotting and LC-MS/MS, but were unable to confirm histone expression at the protein level.
conclusionWe show that all core histone sequences are present in the Lingulodinium transcriptome. The conservation of these sequences, even though histone protein accumulation remains below currently detectable levels, strongly suggests dinoflagellates possess histones.
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