ArticlePloS one2012
Epidermal transglutaminase (TGase 3) is required for proper hair development, but not the formation of the epidermal barrier.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Human Transglutaminases: Updated Insights into Activation Mechanisms, Allosteric Regulation and Disease.International journal of molecular sciences · 2026Review
- Genomic Characterization of the Kazakh Fat-Tailed Coarse-Wool Sheep Breed Using ROH Analysis.Animals : an open access journal from MDPI · 2025Article
- Transglutaminase 1: Emerging Functions beyond Skin.International journal of molecular sciences · 2024Review
- The Evolution of Transglutaminases Underlies the Origin and Loss of Cornified Skin Appendages in Vertebrates.Molecular biology and evolution · 2024Article
- Cornification of keratinocytes is associated with differential changes in the catalytic activity and the immunoreactivity of transglutaminase-1.Scientific reports · 2023Article
- Resolution of Eczema with Multivalent Peptides.JID innovations : skin science from molecules to population health · 2022Article
- Article
- Transglutaminase 6 Is Colocalized and Interacts with Mutant Huntingtin in Huntington Disease Rodent Animal Models.International journal of molecular sciences · 2021Article
- TMT-Based Quantitative Proteomic Analysis Reveals the Effect of Bone Marrow Derived Mesenchymal Stem Cell on Hair Follicle Regeneration.Frontiers in pharmacology · 2021Article
- Review
- Transglutaminase 3 Reduces the Severity of Psoriasis in Imiquimod-Treated Mouse Skin.International journal of molecular sciences · 2020Article
- Transglutaminases in Monocytes and Macrophages.Medical sciences (Basel, Switzerland) · 2018Review
- FineMAV: prioritizing candidate genetic variants driving local adaptations in human populations.Genome biology · 2018Article
- Transglutaminase 2 mediates UV-induced skin inflammation by enhancing inflammatory cytokine production.Cell death & disease · 2017Article
- ADAM17/EGFR axis promotes transglutaminase-dependent skin barrier formation through phospholipase C γ1 and protein kinase C pathways.Scientific reports · 2016Article
- Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome.American journal of human genetics · 2016Article
- ZNF281 contributes to the DNA damage response by controlling the expression of XRCC2 and XRCC4.Oncogene · 2016Article
- Tracking the origins of Yakutian horses and the genetic basis for their fast adaptation to subarctic environments.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The mouse wellhaarig (we) mutations result from defects in epidermal-type transglutaminase 3 (Tgm3).Molecular genetics and metabolism · 2015Article
- Hair follicle morphogenesis and epidermal homeostasis in we/we wal/wal mice with postnatal alopecia.Histochemistry and cell biology · 2015Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Transglutaminases (TGase), a family of cross-linking enzymes present in most cell types, are important in events as diverse as cell-signaling and matrix stabilization. Transglutaminase 1 is crucial in developing the epidermal barrier, however the skin also contains other family members, in particular TGase 3. This isoform is highly expressed in the cornified layer, where it is believed to stabilize the epidermis and its reduction is implicated in psoriasis. To understand the importance of TGase 3 in vivo we have generated and analyzed mice lacking this protein. Surprisingly, these animals display no obvious defect in skin development, no overt changes in barrier function or ability to heal wounds. In contrast, hair lacking TGase 3 is thinner, has major alterations in the cuticle cells and hair protein cross-linking is markedly decreased. Apparently, while TGase 3 is of unique functional importance in hair, in the epidermis loss of TGase 3 can be compensated for by other family members.
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