ArticlePloS one2012
In vivo outer hair cell length changes expose the active process in the cochlea.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- Effect of Contralateral Medial Olivocochlear Feedback on Perceptual Estimates of Cochlear Gain and Compression.Journal of the Association for Research in Otolaryngology : JARO · 2016Trial
- Piezoelectric Biomaterials for Osteochondral Tissue Engineering: Advances, Mechanisms, and Translational Prospects.Journal of functional biomaterials · 2026Review
- Study of organ of Corti motion in the guinea pig base including differential analysis of internal motion.Hearing research · 2025Article
- Cochlear outer hair cell electromotility enhances organ of Corti motion on a cycle-by-cycle basis at high frequencies in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- A role for tectorial membrane mechanics in activating the cochlear amplifier.Scientific reports · 2020Article
- The interplay of organ-of-Corti vibrational modes, not tectorial- membrane resonance, sets outer-hair-cell stereocilia phase to produce cochlear amplification.Hearing research · 2020Review
- Interactions between Passive and Active Vibrations in the Organ of Corti In Vitro.Biophysical journal · 2020Article
- Characterisation of the static offset in the travelling wave in the cochlear basal turn.Pflugers Archiv : European journal of physiology · 2020Article
- Unified cochlear model for low- and high-frequency mammalian hearing.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- Revealing the morphology and function of the cochlea and middle ear with optical coherence tomography.Quantitative imaging in medicine and surgery · 2019Review
- Static length changes of cochlear outer hair cells can tune low-frequency hearing.PLoS computational biology · 2018Article
- Analytical and numerical modeling of the hearing system: Advances towards the assessment of hearing damage.Hearing research · 2017Review
- Reverse transduction measured in the living cochlea by low-coherence heterodyne interferometry.Nature communications · 2016Article
- Stimulus Frequency Otoacoustic Emission Delays and Generating Mechanisms in Guinea Pigs, Chinchillas, and Simulations.Journal of the Association for Research in Otolaryngology : JARO · 2015Article
- Exploring the role of feedback-based auditory reflexes in forward masking by schroeder-phase complexes.Journal of the Association for Research in Otolaryngology : JARO · 2015Article
- Connexin26 (GJB2) deficiency reduces active cochlear amplification leading to late-onset hearing loss.Neuroscience · 2015Article
- Basilar membrane and tectorial membrane stiffness in the CBA/CaJ mouse.Journal of the Association for Research in Otolaryngology : JARO · 2014Article
- Vibration of the organ of Corti within the cochlear apex in mice.Journal of neurophysiology · 2014Article
- Filtering of acoustic signals within the hearing organ.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundMammalian hearing is refined by amplification of the sound-evoked vibration of the cochlear partition. This amplification is at least partly due to forces produced by protein motors residing in the cylindrical body of the outer hair cell. To transmit power to the cochlear partition, it is required that the outer hair cells dynamically change their length, in addition to generating force. These length changes, which have not previously been measured in vivo, must be correctly timed with the acoustic stimulus to produce amplification. METHODOLOGY/PRINCIPAL
findingsUsing in vivo optical coherence tomography, we demonstrate that outer hair cells in living guinea pigs have length changes with unexpected timing and magnitudes that depend on the stimulus level in the sensitive cochlea. CONCLUSIONS/SIGNIFICANCE: The level-dependent length change is a necessary condition for directly validating that power is expended by the active process presumed to underlie normal hearing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.