ArticlePLoS genetics2012
A shared role for RBF1 and dCAP-D3 in the regulation of transcription with consequences for innate immunity.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 48 citations in OpenAlex.
- Condensin I folds the Caenorhabditis elegans genome.Nature genetics · 2024Article
- Condensin-mediated restriction of retrotransposable elements facilitates brain development in Drosophila melanogaster.Nature communications · 2024Article
- Resistance and virulence genes characteristic of a South Asia Clade (I) Candida auris strain isolated from blood in Beijing.Clinics (Sao Paulo, Brazil) · 2024Article
- NCAPD2 serves as a potential prognostic biomarker for lung adenocarcinoma and promotes cell proliferation, migration, invasion and cell cycleOncology research · 2024Article
- Condensin I and condensin II proteins form a LINE-1 dependent super condensin complex and cooperate to repress LINE-1.Nucleic acids research · 2022Article
- NCAPD3 enhances Warburg effect through c-myc and E2F1 and promotes the occurrence and progression of colorectal cancer.Journal of experimental & clinical cancer research : CR · 2022Article
- Potential roles of condensin in genome organization and beyond in fission yeast.Journal of microbiology (Seoul, Korea) · 2021Review
- Condensin I is required for faithful meiosis in Drosophila males.Chromosoma · 2020Article
- Article
- Diversification of Retinoblastoma Protein Function Associated with Cis and Trans Adaptations.Molecular biology and evolution · 2019Article
- Condensin II protein dysfunction impacts mitochondrial respiration and mitochondrial oxidative stress responses.Journal of cell science · 2019Article
- Recurrent Losses and Rapid Evolution of the Condensin II Complex in Insects.Molecular biology and evolution · 2019Article
- Condensin action and compaction.Current genetics · 2019Review
- Epigenetics, DNA Organization, and Inflammatory Bowel Disease.Inflammatory bowel diseases · 2019Review
- Comparing and Contrasting the Effects ofGenetics · 2018Article
- Article
- Caenorhabditis elegans Dosage Compensation: Insights into Condensin-Mediated Gene Regulation.Trends in genetics : TIG · 2018Review
- The loading of condensin in the context of chromatin.Current genetics · 2017Review
- Article
- Drosophila Condensin II subunit Chromosome-associated protein D3 regulates cell fate determination through non-cell-autonomous signaling.Development (Cambridge, England) · 2016Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
Abstract
Previously, we discovered a conserved interaction between RB proteins and the Condensin II protein CAP-D3 that is important for ensuring uniform chromatin condensation during mitotic prophase. The Drosophila melanogaster homologs RBF1 and dCAP-D3 co-localize on non-dividing polytene chromatin, suggesting the existence of a shared, non-mitotic role for these two proteins. Here, we show that the absence of RBF1 and dCAP-D3 alters the expression of many of the same genes in larvae and adult flies. Strikingly, most of the genes affected by the loss of RBF1 and dCAP-D3 are not classic cell cycle genes but are developmentally regulated genes with tissue-specific functions and these genes tend to be located in gene clusters. Our data reveal that RBF1 and dCAP-D3 are needed in fat body cells to activate transcription of clusters of antimicrobial peptide (AMP) genes. AMPs are important for innate immunity, and loss of either dCAP-D3 or RBF1 regulation results in a decrease in the ability to clear bacteria. Interestingly, in the adult fat body, RBF1 and dCAP-D3 bind to regions flanking an AMP gene cluster both prior to and following bacterial infection. These results describe a novel, non-mitotic role for the RBF1 and dCAP-D3 proteins in activation of the Drosophila immune system and suggest dCAP-D3 has an important role at specific subsets of RBF1-dependent genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.