ArticlePLoS pathogens2012
The baculovirus uses a captured host phosphatase to induce enhanced locomotory activity in host caterpillars.
Article in PLoS pathogens, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 92 citations in OpenAlex.
- Article
- Article
- Chemosensory protein 3 is a brain host factor for the induction of enhanced-locomotory activity in the BmNPV-silkworm infection model.PLoS pathogens · 2025Article
- Experimental and evolutionary evidence for horizontal transfer of an envelope fusion protein gene between thogotoviruses and baculoviruses.Journal of virology · 2025Article
- Viral- and fungal-mediated behavioral manipulation of hosts: summit disease.Applied microbiology and biotechnology · 2024Review
- Entomophthovirus: an insect-derived iflavirus that infects a behavior-manipulating fungal pathogen of dipterans.G3 (Bethesda, Md.) · 2024Article
- Baculovirus entry into the central nervous system ofOpen biology · 2024Article
- A Lac Repressor-Inducible Baculovirus Expression Vector for Controlling Adeno-Associated Virus Capsid Ratios.Viruses · 2023Article
- The genus Entomophthora: bringing the insect destroyers into the twenty-first century.IMA fungus · 2021Review
- Article
- Insect Behavioral Change and the Potential Contributions of Neuroinflammation-A Call for Future Research.Genes · 2021Review
- The RNA phosphatase PIR-1 regulates endogenous small RNA pathways in C. elegans.Molecular cell · 2021Article
- High-resolution analysis of baculovirus-induced host manipulation in the domestic silkworm,Parasitology · 2021Article
- Intraguild predation decreases predator fitness with potentially varying effects on pathogen transmission in a herbivore host.Oecologia · 2020Article
- Genetic Underpinnings of Host Manipulation byG3 (Bethesda, Md.) · 2020Article
- Entomopathogenic Viruses in the Neotropics: Current Status and Recently Discovered Species.Neotropical entomology · 2020Review
- Zombie ant death grip due to hypercontracted mandibular muscles.The Journal of experimental biology · 2019Article
- Cross-talking between baculoviruses and host insects towards a successful infection.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Article
- Unique sex determination system in the silkworm, Bombyx mori: current status and beyond.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2018Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The baculovirus is a classic example of a parasite that alters the behavior or physiology of its host so that progeny transmission is maximized. Baculoviruses do this by inducing enhanced locomotory activity (ELA) that causes the host caterpillars to climb to the upper foliage of plants. We previously reported that this behavior is not induced in silkworms that are infected with a mutant baculovirus lacking its protein tyrosine phosphatase (ptp) gene, a gene likely captured from an ancestral host. Here we show that the product of the ptp gene, PTP, associates with baculovirus ORF1629 as a virion structural protein, but surprisingly phosphatase activity associated with PTP was not required for the induction of ELA. Interestingly, the ptp knockout baculovirus showed significantly reduced infectivity of larval brain tissues. Collectively, we show that the modern baculovirus uses the host-derived phosphatase to establish adequate infection for ELA as a virion-associated structural protein rather than as an enzyme.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.