ArticlePLoS computational biology2012
Comprehensive modelling of the Neurospora circadian clock and its temperature compensation.
Article in PLoS computational biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Comparative mathematical modeling reveals the differential effects of high-fat diet and ketogenic diet on the PI3K-Akt signaling pathway in heart.Nutrition & metabolism · 2024Article
- Circadian regulation of metabolism across photosynthetic organisms.The Plant journal : for cell and molecular biology · 2023Review
- Data-driven modelling captures dynamics of the circadian clock of Neurospora crassa.PLoS computational biology · 2022Article
- Principles underlying the complex dynamics of temperature entrainment by a circadian clock.iScience · 2021Article
- Circadian rhythm shows potential for mRNA efficiency and self-organized division of labor in multinucleate cells.PLoS computational biology · 2021Article
- ECHO: an application for detection and analysis of oscillators identifies metabolic regulation on genome-wide circadian output.Bioinformatics (Oxford, England) · 2020Article
- FRQ-CK1 interaction determines the period of circadian rhythms in Neurospora.Nature communications · 2019Article
- Non-sinusoidal Waveform in Temperature-Compensated Circadian Oscillations.Biophysical journal · 2019Article
- Modeling Reveals a Key Mechanism for Light-Dependent Phase Shifts of Neurospora Circadian Rhythms.Biophysical journal · 2018Article
- Circadian Rhythms inACM-BCB ... ... : the ... ACM Conference on Bioinformatics, Computational Biology and Biomedicine. ACM Conference on Bioinformatics, Computational Biology and Biomedicine · 2017Article
- Systems Biology-Derived Discoveries of Intrinsic Clocks.Frontiers in neurology · 2017Review
- Protein sequestration versus Hill-type repression in circadian clock models.IET systems biology · 2016Review
- Asynchronous τ-leaping.The Journal of chemical physics · 2016Article
- Circadian systems biology: When time matters.Computational and structural biotechnology journal · 2015Review
- Engineered temperature compensation in a synthetic genetic clock.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The Neurospora photoreceptor VIVID exerts negative and positive control on light sensing to achieve adaptation.Molecular systems biology · 2013Article
- Mathematical modeling of an oscillating gene circuit to unravel the circadian clock network of Arabidopsis thaliana.Frontiers in plant science · 2013Article
- Exploring the genetic control of glycolytic oscillations in Saccharomyces cerevisiae.BMC systems biology · 2012Article
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Authors and funding
5 authors.
Funding
Abstract
Circadian clocks provide an internal measure of external time allowing organisms to anticipate and exploit predictable daily changes in the environment. Rhythms driven by circadian clocks have a temperature compensated periodicity of approximately 24 hours that persists in constant conditions and can be reset by environmental time cues. Computational modelling has aided our understanding of the molecular mechanisms of circadian clocks, nevertheless it remains a major challenge to integrate the large number of clock components and their interactions into a single, comprehensive model that is able to account for the full breadth of clock phenotypes. Here we present a comprehensive dynamic model of the Neurospora crassa circadian clock that incorporates its key components and their transcriptional and post-transcriptional regulation. The model accounts for a wide range of clock characteristics including: a periodicity of 21.6 hours, persistent oscillation in constant conditions, arrhythmicity in constant light, resetting by brief light pulses, and entrainment to full photoperiods. Crucial components influencing the period and amplitude of oscillations were identified by control analysis. Furthermore, simulations enabled us to propose a mechanism for temperature compensation, which is achieved by simultaneously increasing the translation of frq RNA and decreasing the nuclear import of FRQ protein.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.