ArticleThe EMBO journal1990
Chromatin structure of transcriptionally competent and repressed genes.
Article in The EMBO journal, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 176 citations in OpenAlex.
- Two Populations of Viral Minichromosomes Are Present in a Geminivirus-Infected Plant Showing Symptom Remission (Recovery).Journal of virology · 2016Article
- Functional interplay between histone H1 and HMG proteins in chromatin.Biochimica et biophysica acta · 2016Review
- Drosophila H1 regulates the genetic activity of heterochromatin by recruitment of Su(var)3-9.Science (New York, N.Y.) · 2013Article
- Short nucleosome repeats impose rotational modulations on chromatin fibre folding.The EMBO journal · 2012Article
- Genome-wide prediction and analysis of human chromatin boundary elements.Nucleic acids research · 2012Article
- Nucleosome positioning: how is it established, and why does it matter?Developmental biology · 2010Review
- The Saccharomyces cerevisiae linker histone Hho1p is essential for chromatin compaction in stationary phase and is displaced by transcription.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Differential affinity of mammalian histone H1 somatic subtypes for DNA and chromatin.BMC biology · 2007Article
- Role of H1 phosphorylation in rapid GR exchange and function at the MMTV promoter.Histochemistry and cell biology · 2006Article
- Human Arf tumor suppressor specifically interacts with chromatin containing the promoter of rRNA genes.Oncogene · 2004Article
- Construction and analysis of cells lacking the HMGA gene family.Nucleic acids research · 2003Article
- The barrier function of an insulator couples high histone acetylation levels with specific protection of promoter DNA from methylation.Genes & development · 2002Article
- Sir2p exists in two nucleosome-binding complexes with distinct deacetylase activities.The EMBO journal · 2001Article
- DNA methylation and histone deacetylation in the control of gene expression: basic biochemistry to human development and disease.Gene expression · 2000Review
- The distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin: distribution in human fetal fibroblasts.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2000Article
- Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin.Molecular and cellular biology · 1999Article
- Disruption of higher-order folding by core histone acetylation dramatically enhances transcription of nucleosomal arrays by RNA polymerase III.Molecular and cellular biology · 1998Article
- Prothymosin alpha modulates the interaction of histone H1 with chromatin.Nucleic acids research · 1998Article
- Prolonged glucocorticoid exposure dephosphorylates histone H1 and inactivates the MMTV promoter.The EMBO journal · 1998Article
- Implication of localization of human DNA repair enzyme O6-methylguanine-DNA methyltransferase at active transcription sites in transcription-repair coupling of the mutagenic O6-methylguanine lesion.Molecular and cellular biology · 1998Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have compared transcriptionally competent and repressed genes with respect to their linker histone content and their ability to fold into higher-order structures. Histones were cross-linked covalently to DNA in chicken erythrocyte and oviduct nuclei by UV irradiation, and the DNA that was immunoprecipitated with anti-H1 and (for erythrocytes) anti-H5 antibodies was analysed for particular DNA sequences. None of the sequences investigated was free of H1 (H5). However, in mature erythrocytes the tissue-specific adult beta-globin gene (beta A) appears to be partially depleted of H5, and both the beta-globin gene and the H5 gene (also tissue-specific), as well as the 'housekeeping' beta-actin gene, appear to be partially depleted of H1 relative to inactive genes; in oviduct slight H1-depletion is detected on the ovalbumin gene relative to genes that are inactive in this tissue and the actin gene. Transcriptionally competent erythrocyte chromatin fragments, in contrast to inactive fragments, are unable to self-associate into 'pseudo-higher-order structures'. This is likely to be a consequence of the partial depletion of H5 and/or H1 in active chromatin, resulting in the breakdown of (probably cooperative) interactions between H5 and/or H1 molecules that otherwise mediate the assembly of pseudo-higher-order structures in vitro and a stable 30 nm chromatin filament in vivo.
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