ArticleMediators of inflammation2012
Chemokine and free fatty acid levels in insulin-resistant state of successful pregnancy: a preliminary observation.
Article in Mediators of inflammation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Emerging evidence-based inter-conception cares for prevention of hypertensive disorders of pregnancy.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Chemokine profile in women with moderate to severe anxiety and depression during pregnancy.BMC pregnancy and childbirth · 2021Article
- Association between serum free fatty acid levels and nonalcoholic fatty liver disease: a cross-sectional study.Scientific reports · 2014Article
- Adiponectin and IGFBP-1 in the development of gestational diabetes in obese mothers.BMJ open diabetes research & care · 2014Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased insulin resistance and inflammatory action are observed in pregnancy-induced hypertension (PIH), but similar insulin resistance is observed also in successful pregnancy. To estimate insulin resistance and inflammatory activity in normal pregnancy and PIH, serum concentrations of free fatty acids (FFA; corrected with albumin to estimate unbound FFA), monocyte chemoattractant protein (MCP)-1, and high-molecular weight (HMW) adiponectin were measured in severe PIH patients with a BMI less than 25 kg/m(2) and were measured 3 times during the course of pregnancy in women with normal pregnancies. FFA/albumin, MCP-1, and HMW adiponectin concentrations were significantly higher in PIH patients than in women with normal pregnancies. The 3 measurements of FFA/albumin showed a significant increase through the course of uncomplicated pregnancies. In contrast, MCP-1 and HMW adiponectin were significantly decreased during the course of pregnancy. These results suggest that the reduced MCP-1 concentration in normal pregnancy may be a pathway to inhibit the induction of pathological features from physiological insulin resistance and homeostatic inflammation.
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Registered trials
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