ArticleThe EMBO journal1990
Negative autoregulation of c-myc gene expression is inactivated in transformed cells.
Article in The EMBO journal, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 111 citations in OpenAlex.
- Targeting SUMOylation in ovarian cancer: Sensitivity, resistance, and the role of MYC.iScience · 2025Article
- Article
- Overexpressed c-Myc Sensitizes Cells to TH1579, a Mitotic Arrest and Oxidative DNA Damage Inducer.Biomolecules · 2022Article
- Reversible Myc hypomorphism identifies a key Myc-dependency in early cancer evolution.Nature communications · 2022Article
- Article
- MYC and RAS are unable to cooperate in overcoming cellular senescence and apoptosis in normal human fibroblasts.Cell cycle (Georgetown, Tex.) · 2018Article
- Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis.Biochimica et biophysica acta · 2015Review
- MYC association with cancer risk and a new model of MYC-mediated repression.Cold Spring Harbor perspectives in medicine · 2014Review
- An overview of MYC and its interactome.Cold Spring Harbor perspectives in medicine · 2014Review
- MYC acts via the PTEN tumor suppressor to elicit autoregulation and genome-wide gene repression by activation of the Ezh2 methyltransferase.Cancer research · 2013Article
- SKP2 oncogene is a direct MYC target gene and MYC down-regulates p27(KIP1) through SKP2 in human leukemia cells.The Journal of biological chemistry · 2011Article
- Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation.PloS one · 2011Article
- Su(z)2 antagonizes auto-repression of Myc in Drosophila, increasing Myc levels and subsequent trans-activation.PloS one · 2009Article
- Feedback regulation of c-Myc by ribosomal protein L11.Cell cycle (Georgetown, Tex.) · 2007Review
- Article
- Polycomb mediates Myc autorepression and its transcriptional control of many loci in Drosophila.Genes & development · 2005Article
- Autorepression of c-myc requires both initiator and E2F-binding site elements and cooperation with the p107 gene product.Oncogene · 2004Article
- Negative autoregulation of BCL-6 is bypassed by genetic alterations in diffuse large B cell lymphomas.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Myc is an essential negative regulator of platelet-derived growth factor beta receptor expression.Molecular and cellular biology · 2000Article
- c-Myc antagonizes the effect of p53 on apoptosis and p21WAF1 transactivation in K562 leukemia cells.Oncogene · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Negative feedback regulation of c-myc gene expression has been observed in some, but not all, cell types. In order to demonstrate conclusively the existence of this mechanism and gain insight into the cause of its inactivation, we have directly examined its function in B cells and then investigated its activity in a number of cell types. We demonstrate the existence of negative c-myc autoregulation by showing the rapid, dose dependent and reversible suppression of endogenous c-myc expression in EBV-immortalized B lymphoblastoid cells transfected with a c-myc gene expressed under the control of a heavy metal inducible promoter. Autoregulation occurs at the level of transcriptional initiation and is mediated by at least one stable intermediate or cofactor molecule. The c-myc autoregulatory mechanism was found operative in all (11 of 11) non-tumorigenic cells tested, including normal and immortalized lymphocytes and fibroblasts. However, this mechanism was found to be inactive in all (10 of 10) tumor cell lines derived from a variety of tissues including those carrying normal and oncogenically activated c-myc genes. These data establish the existence of an important regulatory circuit modulating c-myc expression in normal cells and suggest that its inactivation may represent a general regulatory disturbance of transformed cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.