ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Schaffer-specific local field potentials reflect discrete excitatory events at gamma frequency that may fire postsynaptic hippocampal CA1 units.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- TNEA Regulates Hippocampal Oscillation by Improving Inhibitory Synaptic Plasticity to Ameliorates Cognitive Impairment in Alzheimer's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Brain sources composing irregular field potentials have unique temporal signatures.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Multi-Shank 1024 Channels Active SiNAPS Probe for Large Multi-Regional Topographical Electrophysiological Mapping of Neural Dynamics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Sleep microstructure organizes memory replay.Nature · 2025Article
- Intracranial Voltage Profiles from Untangled Human Deep Sources Reveal Multisource Composition and Source Allocation Bias.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Auditory sensory processing induces cortical and thalamic event-related desynchronization in the mouse.PloS one · 2025Article
- Uncovering population contributions to the extracellular potential in the mouse visual system using Laminar Population Analysis.PLoS computational biology · 2024Article
- Multi-shank 1024 channels active SiNAPS probe for large multi-regional topographical electrophysiological mapping of neural dynamics.Research square · 2024Article
- Uncovering population contributions to the extracellular potential in the mouse visual system using Laminar Population Analysis.bioRxiv : the preprint server for biology · 2024Article
- A dietary polyphenol metabolite alters CA1 excitability ex vivo and mildly affects cortico-hippocampal field potential generators in anesthetized animals.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Spatial learning impairments and discoordination of entorhinal-hippocampal circuit coding following prolonged febrile seizures.Hippocampus · 2023Article
- Article
- Dissecting cell-type-specific pathways in medial entorhinal cortical-hippocampal network for episodic memory.Journal of neurochemistry · 2023Review
- Review
- Site-dependent shaping of field potential waveforms.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Uncorrelated bilateral cortical input becomes timed across hippocampal subfields for long waves whereas gamma waves are largely ipsilateral.Frontiers in cellular neuroscience · 2023Article
- Theoretical considerations and supporting evidence for the primary role of source geometry on field potential amplitude and spatial extent.Frontiers in cellular neuroscience · 2023Review
- HectoSTAR μLED Optoelectrodes for Large-Scale, High-Precision In Vivo Opto-Electrophysiology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Gamma rhythm communication between entorhinal cortex and dentate gyrus neuronal assemblies.Science (New York, N.Y.) · 2021Article
- Neocortical Slow Oscillations Implicated in the Generation of Epileptic Spasms.Annals of neurology · 2021Article
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4 authors.
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Abstract
Information processing and exchange between brain nuclei are made through spike series sent by individual neurons in highly irregular temporal patterns. Synchronization in cell assemblies, proposed as a network language for internal neural representations, still has little experimental support. We use a novel technique to extract pathway-specific local field potentials (LFPs) in the hippocampus to explore the ongoing temporal structure of a single presynaptic input, the CA3 Schaffer pathway, and its contribution to the spontaneous output of CA1 units in anesthetized rat. We found that Schaffer-specific LFPs are composed of a regular succession of pulse-like excitatory packages initiated by spontaneous clustered firing of CA3 pyramidal cells to which individual units contribute variably. A fraction of these packages readily induce firing of CA1 pyramidal cells and interneurons, the so-called Schaffer-driven spikes, revealing the presynaptic origin in the output code of single CA1 units. The output of 70% of CA1 pyramidal neurons contains up to 10% of such spikes. Our results suggest a hierarchical internal operation of the CA3 region based on sequential oscillatory activation of pyramidal cell assemblies whose activity partly gets in the output code at the next station. We conclude that CA1 output may directly reflect the activity of specific ensembles of CA3 neurons. Thus, the fine temporal structure of pathway-specific LFPs, as an accurate readout of the activity of a presynaptic population, is useful in searching for hidden presynaptic code in irregular spikes series of individual neurons and assemblies.
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