ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Dopamine modulation of Ih improves temporal fidelity of spike propagation in an unmyelinated axon.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
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- The influence of hyperpolarization-activated cation current on conduction delay and failure of action potentials along axon related to abnormal functions.Cognitive neurodynamics · 2024Article
- Activity-Dependent Ectopic Spiking in Parvalbumin-Expressing Interneurons of the Neocortex.eNeuro · 2024Article
- Modulation by Neuropeptides with Overlapping Targets Results in Functional Overlap in Oscillatory Circuit Activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Neuronomodulation of Excitable Neurons.Neuroscience bulletin · 2024Review
- The dynamic range of voltage-dependent gap junction signaling is maintained byJournal of neurophysiology · 2022Article
- Neuropeptide Modulation Increases Dendritic Electrical Spread to Restore Neuronal Activity Disrupted by Temperature.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The Effects of Cardiorespiratory and Motor Skill Fitness on Intrinsic Functional Connectivity of Neural Networks in Individuals with Parkinson's Disease.Brain plasticity (Amsterdam, Netherlands) · 2021Article
- Temperature-robust activity patterns arise from coordinated axonal Sodium channel properties.PLoS computational biology · 2020Article
- An axon-specific expression of HCN channels catalyzes fast action potential signaling in GABAergic interneurons.Nature communications · 2020Article
- HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons.eLife · 2019Article
- Modulation of Ion Channels in the Axon: Mechanisms and Function.Frontiers in cellular neuroscience · 2019Review
- Mutual Suppression of Proximal and Distal Axonal Spike Initiation Determines the Output Patterns of a Motor Neuron.Frontiers in cellular neuroscience · 2019Article
- Molecular characterization of putative neuropeptide, amine, diffusible gas and small molecule transmitter biosynthetic enzymes in the eyestalk ganglia of the American lobster, Homarus americanus.Invertebrate neuroscience : IN · 2018Article
- Ionic mechanisms underlying history-dependence of conduction delay in an unmyelinated axon.eLife · 2017Article
- Mechanisms of generation of membrane potential resonance in a neuron with multiple resonant ionic currents.PLoS computational biology · 2017Article
- Axonal Conduction Velocity Measurement.Bio-protocol · 2017Article
- The complexity of small circuits: the stomatogastric nervous system.Current opinion in neurobiology · 2016Review
- Octopamine stabilizes conduction reliability of an unmyelinated axon during hypoxic stress.Journal of neurophysiology · 2016Article
- Monoaminergic tone supports conductance correlations and stabilizes activity features in pattern generating neurons of the lobster, Panulirus interruptus.Frontiers in neural circuits · 2015Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We studied how conduction delays of action potentials in an unmyelinated axon depended on the history of activity and how this dependence was changed by the neuromodulator dopamine (DA). The pyloric dilator axons of the stomatogastric nervous system in the lobster, Homarus americanus, exhibited substantial activity-dependent hyperpolarization and changes in spike shape during repetitive activation. The conduction delays varied by several milliseconds per centimeter, and, during activation with realistic burst patterns or Poisson-like patterns, changes in delay occurred over multiple timescales. The mean delay increased, whereas the resting membrane potential hyperpolarized with a time constant of several minutes. Concomitantly with the mean delay, the variability of delay also increased. The variability of delay was not a linear or monotonic function of instantaneous spike frequency or spike shape parameters, and the relationship between these parameters changed with the increase in mean delay. Hyperpolarization was counteracted by a hyperpolarization-activated inward current (I(h)), and the magnitude of I(h) critically determined the temporal fidelity of spike propagation. Pharmacological block of I(h) increased the change in delay and the variability of delay, and increasing I(h) by application of DA diminished both. Consequently, the temporal fidelity of pattern propagation was substantially improved in DA. Standard measurements of changes in excitability or delay with paired stimuli or tonic stimulation failed to capture the dynamics of spike conduction. These results indicate that spike conduction can be extremely sensitive to the history of axonal activity and to the presence of neuromodulators, with potentially important consequences for temporal coding.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.