ArticleScience translational medicine2012
Prognostic indicators of life-threatening malaria are associated with distinct parasite variant antigen profiles.
Article in Science translational medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 91 citations in OpenAlex.
- Population genomics of virulence genes of Plasmodium falciparum in clinical isolates from Uganda.Scientific reports · 2017Trial
- Plasmodium falciparum malaria parasite var gene expression is modified by host antibodies: longitudinal evidence from controlled infections of Kenyan adults with varying natural exposure.BMC infectious diseases · 2017Trial
- DC8 and DC13 var genes associated with severe malaria bind avidly to diverse endothelial cells.PLoS pathogens · 2013Trial
- upsML: A high-accuracy machine learning classifier for predicting Plasmodium falciparum var gene upstream groups.PloS one · 2026Article
- Measuring changes ineLife · 2025Article
- Plasmodium falciparum expresses fewer var genes at lower levels during asymptomatic dry season infections than clinical malaria cases.PLoS pathogens · 2025Article
- Identification of novel PfEMP1 variants containing domain cassettes 11, 15 and 8 that mediate the Plasmodium falciparum virulence-associated rosetting phenotype.PLoS pathogens · 2025Article
- Neutral vs. non-neutral genetic footprints of Plasmodium falciparum multiclonal infections.PLoS computational biology · 2023Article
- Bayesian estimation of community size and overlap from random subsamples.PLoS computational biology · 2022Article
- Identifying Targets of Protective Antibodies against Severe Malaria in Papua, Indonesia, Using Locally Expressed Domains of Plasmodium falciparum Erythrocyte Membrane Protein 1.Infection and immunity · 2022Article
- Analysis of var Gene Transcription Pattern Using DBLα Tags.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Common virulence gene expression in adult first-time infected malaria patients and severe cases.eLife · 2021Article
- Mapping immune variation andeLife · 2021Article
- Adaptive immunity selects against malaria infection blocking mutations.PLoS computational biology · 2020Article
- Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1-based vaccines to prevent it.Immunological reviews · 2020Review
- Rosetting revisited: a critical look at the evidence for host erythrocyte receptors inParasitology · 2020Review
- Immunity to Severe Malaria: PfEMP1 Tags Tell a Tale.Cell host & microbe · 2019Article
- Bayes-optimal estimation of overlap between populations of fixed size.PLoS computational biology · 2019Article
- ExploringFrontiers in immunology · 2019Article
- Evolutionary analysis of the most polymorphic gene family inWellcome open research · 2019Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
PfEMP1 is a family of cytoadhesive surface antigens expressed on erythrocytes infected with Plasmodium falciparum, the parasite that causes the most severe form of malaria. These surface antigens play a role in immune evasion and are thought to contribute to the pathogenesis of the malaria parasite. Previous studies have suggested a role for a specific subset of PfEMP1 called "group A" in severe malaria. To explore the role of group A PfEMP1 in disease, we measured the expression of the var genes that encode them in parasites from clinical isolates collected from children suffering from malaria. We also looked at the ability of these clinical isolates to induce rosetting of erythrocytes, which indicates a cytoadhesion phenotype that is thought to be important in pathogenesis. These two sets of data were correlated with the presence of two life-threatening manifestations of severe malaria in the children: impaired consciousness and respiratory distress. Using regression analysis, we show that marked rosetting was associated with respiratory distress, whereas elevated expression of group A-like var genes without elevated rosetting was associated with impaired consciousness. The results suggest that manifestations of malarial disease may reflect the distribution of cytoadhesion phenotypes expressed by the infecting parasite population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.