ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2012
Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- The 90 plus: longevity and COVID-19 survival.Molecular psychiatry · 2022Review
- Genes and Longevity of Lifespan.International journal of molecular sciences · 2022Review
- Are Alzheimer's and coronary artery diseases genetically related to longevity?Frontiers in psychiatry · 2022Article
- A Preliminary Study to Investigate the Genetic Background of Longevity Based on Whole-Genome Sequence Data of Two Methuselah Dogs.Frontiers in genetics · 2020Article
- ABO blood group polymorphism has an impact on prostate, kidney and bladder cancer in association with longevity.Oncology letters · 2018Article
- Four Genome-Wide Association Studies Identify New Extreme Longevity Variants.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Lipid and Alzheimer's disease genes associated with healthy aging and longevity in healthy oldest-old.Oncotarget · 2017Article
- Puzzling role of genetic risk factors in human longevity: "risk alleles" as pro-longevity variants.Biogerontology · 2016Review
- Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity.PLoS genetics · 2015Article
- COMT Val158Met polymorphism is associated with blood pressure and lipid levels in general families of Bama longevous area in China.International journal of clinical and experimental pathology · 2015Article
- Sequencing an Ashkenazi reference panel supports population-targeted personal genomics and illuminates Jewish and European origins.Nature communications · 2014Article
- Enrichment of MTHFR 677 T in a Chinese long-lived cohort and its association with lipid modulation.Lipids in health and disease · 2014Article
- Genetics of healthy aging and longevity.Human genetics · 2013Review
- E148Q MEFV mutation carriage and longevity in individuals of Ashkenazi origin.Immunologic research · 2013Article
- Epigenetic determinants of healthy and diseased brain aging and cognition.JAMA neurology · 2013Review
- CR1 and the "vanishing amyloid" hypothesis of Alzheimer's disease.Biological psychiatry · 2013Article
- Microsomal triglyceride transfer protein gene -493G/T polymorphism and its association with serum lipid levels in Bama Zhuang long-living families in China.Lipids in health and disease · 2012Article
- Genetic Structures of Population Cohorts Change with Increasing Age: Implications for Genetic Analyses of Human aging and Life Span.Annals of gerontology and geriatric researchArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
The single nucleotide polymorphism, rs2866164, in the MTP gene, has been associated with human longevity but has not been validated by subsequent longevity studies. Using our population of Ashkenazi Jews, we find that the MTP CC genotype is significantly overrepresented in centenarians and their offspring, as compared with controls (p < .05). However, when we examined MTP CC genotype frequency pattern with aging, we observed a monotonic decline between ages 55-85 years followed by a dramatic enrichment after age 90 years, forming a U-shape pattern (p < .05). Furthermore, the MTP CC genotype was buffered by three validated longevity genotypes (p < .05). This buffering effect was found to confer an enrichment of the MTP CC genotype in centenarians, whereas their absence in CC controls resulted in poorer survivorship (p < .05). Thus, we conclude that MTP CC is a buffered-deleterious genotype and that assessing genotype frequency across aging is essential for discerning longevity from buffered-deleterious genotypes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.