ArticleNucleic acids research2012
Postnatal development- and age-related changes in DNA-methylation patterns in the human genome.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 54 citations in OpenAlex.
- Healthy and premature aging of monocytes and macrophages.Frontiers in immunology · 2025Review
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- Tissue- and ethnicity-independent hypervariable DNA methylation states show evidence of establishment in the early human embryo.Nucleic acids research · 2022Article
- Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters.Molecular psychiatry · 2022Article
- DNA methylation patterns and gene expression from amygdala tissue of mature Brahman cows exposed to prenatal stress.Frontiers in genetics · 2022Article
- Age-related differences in monocyte DNA methylation and immune function in healthy Kenyan adults and children.Immunity & ageing : I & A · 2021Article
- Equivalent DNA methylation variation between monozygotic co-twins and unrelated individuals reveals universal epigenetic inter-individual dissimilarity.Genome biology · 2021Article
- Inter-laboratory adaption of age estimation models by DNA methylation analysis-problems and solutions.International journal of legal medicine · 2020Article
- Article
- Clustered Protocadherins Emerge as Novel Susceptibility Loci for Mental Disorders.Frontiers in neuroscience · 2020Review
- DNA methylation associated with healthy aging of elderly twins.GeroScience · 2018Article
- Identification of Smoking-Associated Differentially Methylated Regions Using Reduced Representation Bisulfite Sequencing and Cell type-Specific Enhancer Activation and Gene Expression.Environmental health perspectives · 2018Article
- Epigenome comparisons reveal linkage between gene expression and postnatal remodeling of chromatin domain topology.PloS one · 2018Article
- Abnormal Epigenetic Regulation of Immune System during Aging.Frontiers in immunology · 2018Review
- Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders.Frontiers in neuroscience · 2017Review
- DNA methylation changes measured in pre-diagnostic peripheral blood samples are associated with smoking and lung cancer risk.International journal of cancer · 2017Article
- Epigenetics and Oxidative Stress in Aging.Oxidative medicine and cellular longevity · 2017Review
- Short-term calorie restriction ameliorates genomewide, age-related alterations in DNA methylation.Aging cell · 2016Article
- Identification of novel candidate drivers connecting different dysfunctional levels for lung adenocarcinoma using protein-protein interactions and a shortest path approach.Scientific reports · 2016Article
- Mechanisms Underlying T Cell Immunosenescence: Aging and Cytomegalovirus Infection.Frontiers in microbiology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Alterations in DNA methylation have been reported to occur during development and aging; however, much remains to be learned regarding post-natal and age-associated epigenome dynamics, and few if any investigations have compared human methylome patterns on a whole genome basis in cells from newborns and adults. The aim of this study was to reveal genomic regions with distinct structure and sequence characteristics that render them subject to dynamic post-natal developmental remodeling or age-related dysregulation of epigenome structure. DNA samples derived from peripheral blood monocytes and in vitro differentiated dendritic cells were analyzed by methylated DNA Immunoprecipitation (MeDIP) or, for selected loci, bisulfite modification, followed by next generation sequencing. Regions of interest that emerged from the analysis included tandem or interspersed-tandem gene sequence repeats (PCDHG, FAM90A, HRNR, ECEL1P2), and genes with strong homology to other family members elsewhere in the genome (FZD1, FZD7 and FGF17). Our results raise the possibility that selected gene sequences with highly homologous copies may serve to facilitate, perhaps even provide a clock-like function for, developmental and age-related epigenome remodeling. If so, this would represent a fundamental feature of genome architecture in higher eukaryotic organisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.