ArticleThe Journal of physiology2012
Mechanical regulation of fibroblast migration and collagen remodelling in healing myocardial infarcts.
Article in The Journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 77 citations in OpenAlex.
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- Biomimetic Electrospun Scaffold-Based In Vitro Model Resembling the Hallmarks of Human Myocardial Fibrotic Tissue.ACS biomaterials science & engineering · 2023Article
- Fourier analysis of collagen bundle orientation in myocardial infarction scars.Histochemistry and cell biology · 2022Article
- Volumetric growth of soft tissues evaluated in the current configuration.Biomechanics and modeling in mechanobiology · 2022Article
- Fibroblast mechanotransduction network predicts targets for mechano-adaptive infarct therapies.eLife · 2022Article
- Intersection of stem cell biology and engineering towards next generationFrontiers in bioengineering and biotechnology · 2022Review
- Fabrication and characterization methods for investigating cell-matrix interactions in environments possessing spatial orientation heterogeneity.Acta biomaterialia · 2021Article
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- Development of a Collagen Fibre Remodelling Rupture Risk Metric for Potentially Vulnerable Carotid Artery Atherosclerotic Plaques.Frontiers in physiology · 2021Article
- Infarct Collagen Topography Regulates Fibroblast Fate via p38-Yes-Associated Protein Transcriptional Enhanced Associate Domain Signals.Circulation research · 2020Article
- Biomechanics of infarcted left ventricle: a review of modelling.Biomedical engineering letters · 2020Review
- Stretch-activated current in human atrial myocytes and NaBiomedical engineering online · 2019Article
- Spatial scaling in multiscale models: methods for coupling agent-based and finite-element models of wound healing.Biomechanics and modeling in mechanobiology · 2019Article
- Effects of Collagen Heterogeneity on Myocardial Infarct Mechanics in a Multiscale Fiber Network Model.Journal of biomechanical engineering · 2019Article
- Identifying important parameters in the inflammatory process with a mathematical model of immune cell influx and macrophage polarization.PLoS computational biology · 2019Article
- Engineering small-caliber vascular grafts from collagen filaments and nanofibers with comparable mechanical properties to native vessels.Biofabrication · 2019Article
- Model First and Ask Questions Later: Confessions of a Reformed Experimentalist.Journal of biomechanical engineering · 2019Article
- Coupled agent-based and hyperelastic modelling of the left ventricle post-myocardial infarction.International journal for numerical methods in biomedical engineering · 2019Article
- Multiscale Coupling of an Agent-Based Model of Tissue Fibrosis and a Logic-Based Model of Intracellular Signaling.Frontiers in physiology · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Effective management of healing and remodelling after myocardial infarction is an important problem in modern cardiology practice. We have recently shown that the level of infarct anisotropy is a critical determinant of heart function following a large anterior infarction, which suggests that therapeutic gains may be realized by controlling infarct anisotropy. However, factors regulating infarct anisotropy are not well understood. Mechanical, structural and chemical guidance cues have all been shown to regulate alignment of fibroblasts and collagen in vitro, and prior studies have proposed that each of these cues could regulate anisotropy of infarct scar tissue, but understanding of fibroblast behaviour in the complex environment of a healing infarct is lacking. We developed an agent-based model of infarct healing that accounted for the combined influence of these cues on fibroblast alignment, collagen deposition and collagen remodelling. We pooled published experimental data from several sources in order to determine parameter values, then used the model to test the importance of each cue for predicting collagen alignment measurements from a set of recent cryoinfarction experiments. We found that although chemokine gradients and pre-existing matrix structures had important effects on collagen organization, a response of fibroblasts to mechanical cues was critical for correctly predicting collagen alignment in infarct scar. Many proposed therapies for myocardial infarction, such as injection of cells or polymers, alter the mechanics of the infarct region. Our modelling results suggest that such therapies could change the anisotropy of the healing infarct, which could have important functional consequences. This model is therefore a potentially important tool for predicting how such interventions change healing outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.