ArticleGenes and immunity2012
Genome-scale profiling reveals a subset of genes regulated by DNA methylation that program somatic T-cell phenotypes in humans.
Article in Genes and immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 42 citations in OpenAlex.
- Polymorphism of theGenes · 2025Article
- MethAgingDB: a comprehensive DNA methylation database for aging biology.Scientific data · 2025Article
- Epigenetic editing at individual age-associated CpGs affects the genome-wide epigenetic aging landscape.Nature aging · 2025Article
- Differential DNA methylation in infants with IgE- and non-IgE-mediated cow's milk allergy and its association with acquired tolerance.Frontiers in immunology · 2025Article
- DNA Methylation signatures underpinning blood neutrophil to lymphocyte ratio during first week of human life.Nature communications · 2024Observational
- Epigenomic variability is associated with age-specific naïve CD4 T cell response to activation in infants and adolescents.Immunology and cell biology · 2023Article
- Epigenetic regulation of pediatric and neonatal immune responses.Pediatric research · 2022Review
- The Functional DNA Methylation Signatures Relevant to Altered Immune Response of Neonatal T Cells with l-Arginine Supplementation.Nutrients · 2021Article
- Combined prenatal Lactobacillus reuteri and ω-3 supplementation synergistically modulates DNA methylation in neonatal T helper cells.Clinical epigenetics · 2021Article
- Detection of selection signatures for response to Aleutian mink disease virus infection in American mink.Scientific reports · 2021Article
- Epigenetic editing: How cutting-edge targeted epigenetic modification might provide novel avenues for autoimmune disease therapy.Clinical immunology (Orlando, Fla.) · 2018Review
- Factors Affecting the Immunity to Respiratory Syncytial Virus: From Epigenetics to Microbiome.Frontiers in immunology · 2018Review
- HumanMethylation450K Array-Identified Biomarkers Predict Tumour Recurrence/Progression at Initial Diagnosis of High-risk Non-muscle Invasive Bladder Cancer.Biomarkers in cancer · 2018Article
- Grandmaternal stress during pregnancy and DNA methylation of the third generation: an epigenome-wide association study.Translational psychiatry · 2017Article
- Removing unwanted variation in a differential methylation analysis of Illumina HumanMethylation450 array data.Nucleic acids research · 2015Article
- Longitudinal analysis of DNA methylation associated with birth weight and gestational age.Human molecular genetics · 2015Article
- Whole genome methylation array reveals the down-regulation of IGFBP6 and SATB2 by HIV-1.Scientific reports · 2015Article
- Defining CD4 T cell memory by the epigenetic landscape of CpG DNA methylation.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Autoimmune disease in the epigenetic era: how has epigenetics changed our understanding of disease and how can we expect the field to evolve?Expert review of clinical immunology · 2015Review
- Epigenome-wide association study reveals longitudinally stable DNA methylation differences in CD4+ T cells from children with IgE-mediated food allergy.Epigenetics · 2014Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the dynamics and relationship between DNA methylation and gene expression during early T-cell development. Mononuclear cells were collected at birth and at 12 months from 60 infants and were either activated with anti-CD3 for 24 h or cultured in media alone, and the CD4+ T-cell subset purified. DNA and RNA were co-harvested and DNA methylation was measured in 450 000 CpG sites in parallel with expression measurements taken from 25 000 genes. In unstimulated cells, we found that a subset of 1188 differentially methylated loci were associated with a change in expression in 599 genes (adjusted P value<0.01, β-fold >0.1). These genes were enriched in reprogramming regions of the genome known to control pluripotency. In contrast, over 630 genes were induced following low-level T-cell activation, but this was not associated with any significant change in DNA methylation. We conclude that DNA methylation is dynamic during early T-cell development, and has a role in the consolidation of T-cell-specific gene expression. During the early phase of clonal expansion, DNA methylation is stable and therefore appears to be of limited importance in short-term T-cell responsiveness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.