ArticleCell death & disease2012
Human Gyrovirus Apoptin shows a similar subcellular distribution pattern and apoptosis induction as the chicken anaemia virus derived VP3/Apoptin.
Article in Cell death & disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Molecular Characterization of EmergingInternational journal of molecular sciences · 2026Article
- Molecular Characterization ofInternational journal of molecular sciences · 2026Article
- Genetic and recombination analysis of GyVg1 varients from companion animals in central and northwest China.Frontiers in veterinary science · 2025Article
- Detection and Molecular Characterization of Gyrovirus Galga 1 in Chickens in Northern Vietnam Reveals Evidence of Recombination.Animals : an open access journal from MDPI · 2024Article
- Molecular analysis ofThe veterinary quarterly · 2024Article
- Detection ofViruses · 2022Article
- Metagenomic characterisation of additional and novel avian viruses from Australian wild ducks.Scientific reports · 2020Article
- New insights into the evolutionary features of viral overlapping genes by discriminant analysis.Virology · 2020Article
- The Role of Apoptin in Chicken Anemia Virus Replication.Pathogens (Basel, Switzerland) · 2020Review
- Cancer Treatment Goes Viral: Using Viral Proteins to Induce Tumour-Specific Cell Death.Cancers · 2019Review
- VP2 of Chicken Anaemia Virus Interacts with Apoptin for Down-regulation of Apoptosis through De-phosphorylated Threonine 108 on Apoptin.Scientific reports · 2017Article
- Apoptin Gene Delivery by the Functionalized Polyamidoamine (PAMAM) Dendrimer Modified with Ornithine Induces Cell Death of HepG2 Cells.Polymers · 2017Article
- Novel characteristics of the avian gyrovirus 2 genome.Scientific reports · 2017Article
- Avian gyrovirus 2 in poultry, China, 2015-2016.Emerging microbes & infections · 2016Article
- Avian Gyrovirus 2 DNA in Fowl from Live Poultry Markets and in Healthy Humans, China.Emerging infectious diseases · 2015Article
- A gyrovirus infecting a sea bird.Archives of virology · 2015Article
- Transcriptomic Profiling of Virus-Host Cell Interactions following Chicken Anaemia Virus (CAV) Infection in an In Vivo Model.PloS one · 2015Article
- Bortezomib sensitises TRAIL-resistant HPV-positive head and neck cancer cells to TRAIL through a caspase-dependent, E6-independent mechanism.Cell death & disease · 2014Article
- Human-gyrovirus-Apoptin triggers mitochondrial death pathway--Nur77 is required for apoptosis triggering.Neoplasia (New York, N.Y.) · 2014Article
- Identification of a chicken anemia virus variant-related gyrovirus in stray cats in china, 2012.BioMed research international · 2014Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
The chicken anaemia virus-derived protein Apoptin/VP3 (CAV-Apoptin) has the important ability to induce tumour-selective apoptosis in a variety of human cancer cells. Recently the first human Gyrovirus (HGyV) was isolated from a human skin swab. It shows significant structural and organisational resemblance to CAV and encodes a homologue of CAV-Apoptin/VP3. Using overlapping primers we constructed a synthetic human Gyrovirus Apoptin (HGyV-Apoptin) fused to green fluorescent protein in order to compare its apoptotic function in various human cancer cell lines to CAV-Apoptin. HGyV-Apoptin displayed a similar subcellular expression pattern as observed for CAV-Apoptin, marked by translocation to the nucleus of cancer cells, although it is predominantly located in the cytosol of normal human cells. Furthermore, expression of either HGyV-Apoptin or CAV-Apoptin in several cancer cell lines triggered apoptosis at comparable levels. These findings indicate a potential anti-cancer role for HGyV-Apoptin.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.