ArticleJournal of human hypertension2013
Inflammatory markers and blood pressure: sex differences and the effect of fat mass in the CoLaus Study.
Article in Journal of human hypertension, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Development of a Sex-Specific Prevalent Hypertension Discrimination Model in Korean Adults Using Genetic Risk Scores and Clinical Biomarkers: A Cross-Sectional Study.Current issues in molecular biology · 2026Article
- Susceptibility of Women to Cardiovascular Disease and the Prevention Potential of Mind-Body Intervention by Changes in Neural Circuits and Cardiovascular Physiology.Biomolecules · 2021Review
- Effects of Acute Aerobic Exercise Combined with Resistance Exercise on Neurocognitive Performance in Obese Women.Brain sciences · 2020Article
- The association between total homocysteine and blood pressure in two independent Chinese populations.Journal of human hypertension · 2020Article
- Sex difference in the mediation roles of an inflammatory factor (hsCRP) and adipokines on the relationship between adiposity and blood pressure.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Suggestive evidence of a multi-cytokine resistin pathway in humans and its role on cardiovascular events in high-risk individuals.Scientific reports · 2017Article
- Up-regulation of gap junction in peripheral blood T lymphocytes contributes to the inflammatory response in essential hypertension.PloS one · 2017Article
- Soluble urokinase plasminogen activator receptor and hypertension among black South Africans after 5 years.Hypertension research : official journal of the Japanese Society of Hypertension · 2015Article
- Comparison of Fat Mass Percentage and Body Mass Index in Koreans With Spinal Cord Injury According to the Severity and Duration of Motor Paralysis.Annals of rehabilitation medicine · 2015Article
- Article
- Sex differences in T cells in hypertension.Clinical therapeutics · 2014Review
- Inflammatory markers and incident frailty in men and women: the English Longitudinal Study of Ageing.Age (Dordrecht, Netherlands) · 2013Article
- Hypertension: what's sex got to do with it?Physiology (Bethesda, Md.) · 2013Review
- Article
- Molecular Signature of the Immune Response to Yoga Therapy in Stress-related Chronic Disease Conditions: An Insight.International journal of yogaReview
- Prediction of abdominal aortic aneurysm calcification by means of variation of high-sensitivity C-reactive protein.JRSM cardiovascular diseaseArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several studies have reported high levels of inflammatory biomarkers in hypertension, but data coming from the general population are sparse, and sex differences have been little explored. The CoLaus Study is a cross-sectional examination survey in a random sample of 6067 Caucasians aged 35-75 years in Lausanne, Switzerland. Blood pressure (BP) was assessed using a validated oscillometric device. Anthropometric parameters were also measured, including body composition, using electrical bioimpedance. Crude serum levels of interleukin-6 (IL-6), tumor necrosis factor α (TNF-α) and ultrasensitive C-reactive protein (hsCRP) were positively and IL-1β (IL-1β) negatively (P<0.001 for all values), associated with BP. For IL-6, IL-1β and TNF-α, the association disappeared in multivariable analysis, largely explained by differences in age and body mass index, in particular fat mass. On the contrary, hsCRP remained independently and positively associated with systolic (β (95% confidence interval): 1.15 (0.64; 1.65); P<0.001) and diastolic (0.75 (0.42; 1.08); P<0.001) BP. Relationships of hsCRP, IL-6 and TNF-α with BP tended to be stronger in women than in men, partly related to the difference in fat mass, yet the interaction between sex and IL-6 persisted after correction for all tested confounders. In the general population, the associations between inflammatory biomarkers and rising levels of BP are mainly driven by age and fat mass. The stronger associations in women suggest that sex differences might exist in the complex interplay between BP and inflammation.
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