Evidence map›Paper›PMID 22494826›Full record

Trial reportLancet (London, England)2012

Effect on the incidence of pneumonia of vitamin D supplementation by quarterly bolus dose to infants in Kabul: a randomised controlled superiority trial.

Semira Manaseki-Holland, Zabihullah Maroof, Jane Bruce, M Zulf Mughal, Mohammad Isaq Masher, Zulfiqar A Bhutta, Gijs Walraven, Daniel Chandramohan

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Lancet (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00548379 (The Effect of Vitamin D Supplementation on the Incidence of Pneumonia in Children in Afghanistan), which is not on this map. Cited by 96 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 19 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00548379 phase3unknown statusnot on this map

The Effect of Vitamin D Supplementation on the Incidence of Pneumonia in Children in Afghanistan: a Randomized Controlled Trial

TypeinterventionalSponsorLondon School of Hygiene and Tropical MedicineRan2007 to 2009Enrolled3,048ConditionsPneumonia, Vitamin D DeficiencyArmsvitamin D, placebo
3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 19 syntheses or guidelines pooled it, 209 citations in OpenAlex.

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36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Semira Manaseki-HollandSchool of Health and Population Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK. s.manasekiholland@bham.ac.uk
Zabihullah Maroof
Jane Bruce
M Zulf Mughal
Mohammad Isaq Masher
Zulfiqar A Bhutta
Gijs Walraven
Daniel Chandramohan
London School of Hygiene & Tropical Medicine · GBAga Khan Development Network · PKAga Khan University · PKKabul Medical University · AFRoyal Manchester Children's Hospital · GBUniversity of Birmingham · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

backgroundVitamin D has a role in regulating immune function, and its deficiency is a suggested risk factor for childhood pneumonia. Our aim was to assess whether oral supplementation of vitamin D(3) (cholecalciferol) will reduce the incidence and severity of pneumonia in a high-risk infant population.

methodsWe did a randomised placebo-controlled trial to compare oral 100,000 IU (2·5 mg) vitamin D(3) with placebo given to children aged 1-11 months in Kabul, Afghanistan. Randomisation was by use of a computer-generated list. Vitamin D or placebo was given by fieldworkers once every 3 months for 18 months. Children presenting at the study hospital with signs of pneumonia had their diagnosis confirmed radiographically. Our primary outcome was the first or only episode of radiologically confirmed pneumonia. Our analysis was by intention to treat. This study is registered with ClinicalTrials.gov, number NCT00548379.

findings1524 children were assigned to receive vitamin D(3) and 1522 placebo. There was no significant difference between the incidence of first or only pneumonia between the vitamin D (0·145 per child per year, 95% CI 0·129-0·164) and the placebo group (0.137, 0·121-0·155); the incidence rate ratio was 1·06 (95% CI 0·89-1·27). From 652 children during five separate periods of testing serum calcifediol, only one child in each of two testing periods had results greater than 375 nmol/L in the intervention group--a toxic level. INTERPRETATIONS: Quarterly bolus doses of oral vitamin D(3) supplementation to infants are not an effective intervention to reduce the incidence of pneumonia in infants in this setting.

fundingWellcome Trust and British Council.

Indexed as

Dietary SupplementsAfghanistanConfidence IntervalsDeveloping CountriesDose-Response Relationship, DrugDrug Administration ScheduleFemaleFollow-Up StudiesHumansIncidenceInfantInfant, NewbornMalePneumoniaPulse Therapy, DrugReference ValuesVitamin D

Identifiers

PMID22494826
PMCPMC3348565
OpenAlexW2127259382

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.