ArticleBMC medical genetics2012
Non-replication study of a genome-wide association study for hypertension and blood pressure in African Americans.
Article in BMC medical genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality.PLoS genetics · 2016Pooled it
- A meta-analytical assessment of STK39 three well-defined polymorphisms in susceptibility to hypertension.Scientific reports · 2016Pooled it
- STK39 polymorphism is associated with essential hypertension: a systematic review and meta-analysis.PloS one · 2013Pooled it
- T‑cadherin and its impact on human diseases (Review).Molecular medicine reports · 2026Review
- Genes, environment, and African ancestry in cardiometabolic disorders.Trends in endocrinology and metabolism: TEM · 2023Review
- Towards the multileveled and processual conceptualisation of racialised individuals in biomedical research.Synthese · 2023Article
- Unique Associations of DNA Methylation Regions With 24-Hour Blood Pressure Phenotypes in Black Participants.Hypertension (Dallas, Tex. : 1979) · 2022Article
- A genome-wide association and replication study of blood pressure in Ugandan early adolescents.Molecular genetics & genomic medicine · 2019Article
- A Social Determinant of Health May Modify Genetic Associations for Blood Pressure: Evidence From a SNP by Education Interaction in an African American Population.Frontiers in genetics · 2019Article
- Hypertension in African Americans.Current cardiology reports · 2017Review
- WNK signalling pathways in blood pressure regulation.Cellular and molecular life sciences : CMLS · 2017Review
- Explicating heterogeneity of complex traits has strong potential for improving GWAS efficiency.Scientific reports · 2016Article
- Sex-specific association of rs4746172 of VCL gene with hypertension in two Han populations from Southern China.Scientific reports · 2015Article
- Article
- Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study.American journal of hypertension · 2015Article
- Chasing Mendel: five questions for personalized medicine.The Journal of physiology · 2014Review
- Combined effects of smoking and alcohol on metabolic syndrome: the LifeLines cohort study.PloS one · 2014Article
- Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport.Physiological reviews · 2012Review
- The role of the kidney in regulating arterial blood pressure.Nature reviews. Nephrology · 2012Review
- Molecular mechanisms of experimental salt-sensitive hypertension.Journal of the American Heart Association · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundA recent genome wide association study in 1017 African Americans identified several single nucleotide polymorphisms that reached genome-wide significance for systolic blood pressure. We attempted to replicate these findings in an independent sample of 2474 unrelated African Americans in the Milwaukee metropolitan area; 53% were women and 47% were hypertensives.
methodsWe evaluated sixteen top associated SNPs from the above genome wide association study for hypertension as a binary trait or blood pressure as a continuous trait. In addition, we evaluated eight single nucleotide polymorphisms located in two genes (STK-39 and CDH-13) found to be associated with systolic and diastolic blood pressures by other genome wide association studies in European and Amish populations. TaqMan MGB-based chemistry with fluorescent probes was used for genotyping. We had an adequate sample size (80% power) to detect an effect size of 1.2-2.0 for all the single nucleotide polymorphisms for hypertension as a binary trait, and 1% variance in blood pressure as a continuous trait. Quantitative trait analyses were performed both by excluding and also by including subjects on anti-hypertensive therapy (after adjustments were made for anti-hypertensive medications).
resultsFor all 24 SNPs, no statistically significant differences were noted in the minor allele frequencies between cases and controls. One SNP (rs2146204) showed borderline association (p = 0.006) with hypertension status using recessive model and systolic blood pressure (p = 0.02), but was not significant after adjusting for multiple comparisons. In quantitative trait analyses, among normotensives only, rs12748299 was associated with SBP (p = 0.002). In addition, several nominally significant associations were noted with SBP and DBP among normotensives but none were statistically significant.
conclusionsThis study highlights the importance of replication to confirm the validity of genome wide association study results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.