Evidence map›Paper›PMID 22493854›Full record

ArticleJournal of medical entomology2012

Mosquitocidal properties of natural product compounds isolated from Chinese herbs and synthetic analogs of curcumin.

David M Anstrom, Xia Zhou, Cody N Kalk, Baoan Song, Que Lan

Open access · bronzeAbstract read
In one paragraph

Article in Journal of medical entomology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Sterol Carrier Protein Inhibition-Based Control of Mosquito Vectors: Current Knowledge and Future Perspectives.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2019
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

David M AnstromDepartment of Entomology, University of Wisconsin, 840 Russell Labs, 1630 Linden Drive, Madison, WI 53706, USA.
Xia Zhou
Cody N Kalk
Baoan Song
Que Lan
University of Wisconsin System · USGuizhou University · CN

Funding

Intracellular transfer of cholesterol in mosquitoesR01AI067422 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI LAN, QUE · 2006 to 2010
$1.2M
NIAID NIH HHS R01 AI067422
6 · The paper itself

Abstract

Because of resistance to current insecticides and to environmental, health, and regulatory concerns, naturally occurring compounds and their derivatives are of increasing interest for the development of new insecticidal compounds against vectors of disease-causing pathogens. Fifty-eight compounds, either extracted and purified from plants native to China or synthetic analogs of curcumin, were evaluated for both their larvicidal activity against Aedes aegypti (L.) and their ability to inhibit binding of cholesterol to Ae. aegypti sterol carrier protein-2 in vitro. Of the compounds tested, curcumin analogs seem especially promising in that of 24 compounds tested five were inhibitors of Ae. aegypti sterol carrier protein-2 with EC50 values ranging from 0.65 to 62.87 microM, and three curcumin analogs exhibited larvicidal activity against fourth instar Ae. aegypti larvae with LC50 values ranging from 17.29 to 27.90 microM. Adding to the attractiveness of synthetic curcumin analogs is the relative ease of synthesizing a large diversity of compounds; only a small fraction of such diversity has been sampled in this study.

Indexed as

AedesAnimalsCarrier ProteinsCholesterolCurcuminDrugs, Chinese HerbalInsecticidesMosquito ControlPlant ExtractsCarrier ProteinsCholesterolCurcuminDrugs, Chinese HerbalInsecticidesPlant Extractssterol carrier proteins

Identifiers

PMID22493854
PMCPMC3538819
OpenAlexW2157226098

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.