ArticleJournal of the Korean Surgical Society2012
Oncologic manifestations of neurofibromatosis type 1 in Korea.
Article in Journal of the Korean Surgical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Review
- Co-occurrence of breast cancer and malignant peripheral nerve sheath tumor in a patient with neurofibromatosis type 1.International cancer conference journal · 2025Article
- Malignant peripheral nerve sheath tumor of the cervix in an adolescent with neurofibromatosis type 1: A case report and review of literature.The journal of obstetrics and gynaecology research · 2024Review
- Case report of ascending colon cancer and multiple jejunal GISTs in a patient with neurofibromatosis type 1 (NF1).BMC cancer · 2019Article
- Increased breast cancer risk in women with neurofibromatosis type 1: a meta-analysis and systematic review of the literature.Hereditary cancer in clinical practice · 2019Article
- Rectal carcinoma and multiple gastrointestinal stromal tumors (GIST) of the small intestine in a patient with neurofibromatosis type 1: a case report.World journal of surgical oncology · 2017Article
- Synchronous neuroendocrine tumor and non-small-cell lung cancer in neurofibromatosis type 1.Clinical case reports · 2015Article
- A genetic model for gallbladder carcinogenesis and its dissemination.Annals of oncology : official journal of the European Society for Medical Oncology · 2014Review
- A long-term survival case of a primary malignant intracerebral nerve sheath tumor.Journal of Korean Neurosurgical Society · 2013Article
- Multiple gastrointestinal stromal tumors and pheochromocytoma in a patient with von Recklinghausen's disease.International journal of surgery case reports · 2013Article
- Rapid diagnosis of combined multifocal gastrointestinal stromal tumours and coeliac disease in a patient with type 1 neurofibromatosis.JRSM short reports · 2013Article
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Authors and funding
7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to investigate the incidence and spectrum of malignant tumors in Korean neurofibromatosis type 1 (NF1) patients.
methodsWe retrospectively reviewed 125 patients who were diagnosed with NF1 at a single institution from 1995 to 2010. The incidence, location, histologic type, and radiologic findings of malignant tumors as well as development of multiple primary tumors were analyzed.
resultsEighteen malignant tumors occurred in 16 patients (12.8%) among 125 Korean NF1 patients; 9 carcinomas, 8 sarcomas and 1 central nervous system (CNS) tumor. Five tumors were of nervous system origin and 13 were non-nervous system tumors. The locations of the tumors were as follow: 1 CNS, 2 lung, 3 breast, 3 stomach, 3 small bowel, 1 colon, 1 liver, 1 uterus, 1 neck, and 2 in extremities. Three malignant peripheral nerve sheath tumors (MPNSTs) occurred at the neck and extremity, and one in the liver. All three gastrointestinal stromal tumors (GISTs) had multiple tumors in the jejunum, and one MPNST and one pheochromocytoma were accompanied in two GISTs. Multiple primary tumors, benign or malignant were reported in 4 patients (25.0%), synchronously or metachronously.
conclusionKorean NF1 patients had a high risk of developing malignant tumors. The common malignant tumors in Koreans such as breast, lung and stomach cancers developed frequently in addition to the NF1-related tumors such as MPNST or GIST.
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