Evidence map›Paper›PMID 22493743›Full record

ArticlePloS one2012

Structural and functional analysis of the symmetrical Type I restriction endonuclease R.EcoR124I

James E N Taylor, Anna Swiderska, Jean-Baptiste Artero, Philip Callow, Geoff Kneale

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

James E N Taylor *Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, Portsmouth, United Kingdom.
Anna Swiderska *Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, Portsmouth, United Kingdom.
Jean-Baptiste ArteroPartnership for Structural Biology, Institut Laue-Langevin, Grenoble, France.
Philip CallowPartnership for Structural Biology, Institut Laue-Langevin, Grenoble, France.
Geoff KnealeInstitute of Biomedical and Biomolecular Sciences, University of Portsmouth, Portsmouth, United Kingdom.
University of Portsmouth · GBInstitut Laue-Langevin · FRKeele University · GB

Funding

Wellcome Trust 080304Wellcome Trust 080304/Z/06/Z
6 · The paper itself

Abstract

Type I restriction-modification (RM) systems are comprised of two multi-subunit enzymes, the methyltransferase (∼160 kDa), responsible for methylation of DNA, and the restriction endonuclease (∼400 kDa), responsible for DNA cleavage. Both enzymes share a number of subunits. An engineered RM system, EcoR124I

Indexed as

Base SequenceBinding SitesDeoxyribonucleases, Type I Site-SpecificDNAElectrophoretic Mobility Shift AssayEscherichia coliMethyltransferasesModels, MolecularMolecular Sequence DataNeutron DiffractionProtein ConformationProtein EngineeringProtein MultimerizationProtein Structure, TertiaryProtein SubunitsScattering, Small AngleDeoxyribonucleases, Type I Site-SpecificDNAendodeoxyribonuclease EcoR124IMethyltransferasesProtein Subunits

Identifiers

PMID22493743
PMCPMC3320862
OpenAlexW2153410616

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.