ArticlePloS one2012
Emergent functional properties of neuronal networks with controlled topology.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
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- Controlled deposition of human neural stem cells on fiber substrates using gel encapsulation.PloS one · 2026Article
- Harnessing Intelligence from Brain Cells In Vitro.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025Review
- Advances in large-scale electrophysiology with high-density microelectrode arrays.Lab on a chip · 2025Review
- Spontaneous Dynamics Predict the Effects of Targeted Intervention in Hippocampal Neuronal Cultures.bioRxiv : the preprint server for biology · 2025Article
- Nanomagnetic Guidance Shapes the Structure-Function Relationship of Developing Cortical Networks.Nano letters · 2024Article
- Graphene and its hybrid nanocomposite: A Metamorphoses elevation in the field of tissue engineering.Heliyon · 2024Review
- Investigating the interplay between segregation and integration in developing cortical assemblies.Frontiers in cellular neuroscience · 2024Article
- Connectivity and network burst properties of in-vitro neuronal networks induced by a clustered structure with alginate hydrogel patterning.Biomedical engineering letters · 2023Article
- Multiple neuron clusters on Micro-Electrode Arrays as an in vitro model of brain network.Scientific reports · 2023Article
- Portrait of intense communications within microfluidic neural networks.Scientific reports · 2023Article
- Microenvironments Matter: Advances in Brain-on-Chip.Biosensors · 2023Review
- Rich dynamics and functional organization on topographically designed neuronal networksiScience · 2022Article
- Comparison of fractal and grid electrodes for studying the effects of spatial confinement on dissociated retinal neuronal and glial behavior.Scientific reports · 2022Article
- Stimulus-Evoked Activity Modulation of In Vitro Engineered Cortical and Hippocampal Networks.Micromachines · 2022Article
- Topologically controlled circuits of human iPSC-derived neurons for electrophysiology recordings.Lab on a chip · 2022Article
- Neurons-on-a-Chip:Molecules and cells · 2022Review
- Long-term morphological and functional dynamics of human stem cell-derived neuronal networks on high-density micro-electrode arrays.Frontiers in neuroscience · 2022Article
- Spontaneous and Perturbational Complexity in Cortical Cultures.Brain sciences · 2021Article
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Authors and funding
10 authors.
Funding
Abstract
The interplay between anatomical connectivity and dynamics in neural networks plays a key role in the functional properties of the brain and in the associated connectivity changes induced by neural diseases. However, a detailed experimental investigation of this interplay at both cellular and population scales in the living brain is limited by accessibility. Alternatively, to investigate the basic operational principles with morphological, electrophysiological and computational methods, the activity emerging from large in vitro networks of primary neurons organized with imposed topologies can be studied. Here, we validated the use of a new bio-printing approach, which effectively maintains the topology of hippocampal cultures in vitro and investigated, by patch-clamp and MEA electrophysiology, the emerging functional properties of these grid-confined networks. In spite of differences in the organization of physical connectivity, our bio-patterned grid networks retained the key properties of synaptic transmission, short-term plasticity and overall network activity with respect to random networks. Interestingly, the imposed grid topology resulted in a reinforcement of functional connections along orthogonal directions, shorter connectivity links and a greatly increased spiking probability in response to focal stimulation. These results clearly demonstrate that reliable functional studies can nowadays be performed on large neuronal networks in the presence of sustained changes in the physical network connectivity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.