ArticlePloS one2012
Metabonomic profiles delineate the effect of traditional Chinese medicine sini decoction on myocardial infarction in rats.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Recent progress in metabolomic analysis of acute coronary syndrome: a narrative review.Cardiovascular diagnosis and therapy · 2025Review
- Qualitative and Quantitative Analysis of Phytochemicals in Sayeok-Tang via UPLC-Q-Orbitrap-MS and UPLC-TQ-MS/MS.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Traditional Chinese Medicine-based Treatment in Cardiovascular Disease: Potential Mechanisms of Action.Current pharmaceutical biotechnology · 2024Review
- Benzoylaconine improves mitochondrial function in oxygen-glucose deprivation and reperfusion-induced cardiomyocyte injury by activation of the AMPK/PGC-1 axis.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2022Article
- Bacterial diversity in the intestinal mucosa of heart failure rats treated with Sini Decoction.BMC complementary medicine and therapies · 2022Article
- Investigation of the protective mechanism of leonurine against acute myocardial ischemia by an integrated metabolomics and network pharmacology strategy.Frontiers in cardiovascular medicine · 2022Article
- Anti-Liver Fibrosis Activity and the Potential Mode of Action of Ruangan Granules: Integrated Network Pharmacology and Metabolomics.Frontiers in pharmacology · 2021Article
- NMR as a "Gold Standard" Method in Drug Design and Discovery.Molecules (Basel, Switzerland) · 2020Review
- Mechanism ofMolecules (Basel, Switzerland) · 2018Article
- Analysis of gene expression and functional changes of adrenal gland in a rat model of kidney yang deficiency syndrome treated withExperimental and therapeutic medicine · 2018Article
- UPLC‑QTOFMS‑based metabolomic analysis of the serum of hypoxic preconditioning mice.Molecular medicine reports · 2017Article
- Three serum metabolite signatures for diagnosing low-grade and high-grade bladder cancer.Scientific reports · 2017Article
- Shaofu Zhuyu decoction ameliorates obesity-mediated hepatic steatosis and systemic inflammation by regulating metabolic pathways.PloS one · 2017Article
- Cardiovascular Disease Chemogenomics Knowledgebase-guided Target Identification and Drug Synergy Mechanism Study of an Herbal Formula.Scientific reports · 2016Article
- Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association.Circulation research · 2016Review
- Drug target identification using network analysis: Taking active components in Sini decoction as an example.Scientific reports · 2016Article
- Metabolite Modulation in Human Plasma in the Early Phase of Acclimatization to Hypobaric Hypoxia.Scientific reports · 2016Article
- Chinese Herbal Medicine on Cardiovascular Diseases and the Mechanisms of Action.Frontiers in pharmacology · 2016Review
- Three plasma metabolite signatures for diagnosing high altitude pulmonary edema.Scientific reports · 2015Article
- Urinary Metabolomic Profiling Reveals the Effect of Shenfu Decoction on Chronic Heart Failure in Rats.Molecules (Basel, Switzerland) · 2015Article
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Authors and funding
8 authors.
Funding
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Abstract
backgroundIn spite of great advances in target-oriented Western medicine for treating myocardial infarction (MI), it is still a leading cause of death in a worldwide epidemic. In contrast to Western medicine, Traditional Chinese medicine (TCM) uses a holistic and synergistic approach to restore the balance of Yin-Yang of body energy so the body's normal function can be restored. Sini decoction (SND) is a well-known formula of TCM which has been used to treat MI for many years. However, its holistic activity evaluation and mechanistic understanding are still lacking due to its complex components. METHODOLOGY/PRINCIPAL
findingsA urinary metabonomic method based on nuclear magnetic resonance and ultra high-performance liquid chromatography coupled to mass spectrometry was developed to characterize MI-related metabolic profiles and delineate the effect of SND on MI. With Elastic Net for classification and selection of biomarkers, nineteen potential biomarkers in rat urine were screened out, primarily related to myocardial energy metabolism, including the glycolysis, citrate cycle, amino acid metabolism, purine metabolism and pyrimidine metabolism. With the altered metabolism pathways as possible drug targets, we systematically analyze the therapeutic effect of SND, which demonstrated that SND administration could provide satisfactory effect on MI through partially regulating the perturbed myocardial energy metabolism. CONCLUSIONS/SIGNIFICANCE: Our results showed that metabonomic approach offers a useful tool to identify MI-related biomarkers and provides a new methodological cue for systematically dissecting the underlying efficacies and mechanisms of TCM in treating MI.
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