ArticlePloS one2012
Mutation accumulation may be a minor force in shaping life history traits.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Ageing as a two-phase process: theoretical framework.Frontiers in aging · 2024Article
- Phenotypic plasticity of senescence inRoyal Society open science · 2020Article
- Extrinsic Mortality Can Shape Life-History Traits, Including Senescence.Evolutionary biology · 2018Article
- Article
- Testing evolutionary models of senescence: traditional approaches and future directions.Human genetics · 2014Review
- Evolutionary shaping of demographic schedules.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Evolution. Getting to the root of aging.Science (New York, N.Y.) · 2012Article
- Mutation accumulation may only be a minor force in shaping life-history traits, even when reproduction is sexual.PloS one · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Is senescence the adaptive result of tradeoffs between younger and older ages or the nonadaptive burden of deleterious mutations that act at older ages? To shed new light on this unresolved question we combine adaptive and nonadaptive processes in a single model. Our model uses Penna's bit-strings to capture different age-specific mutational patterns. Each pattern represents a genotype and for each genotype we find the life history strategy that maximizes fitness. Genotypes compete with each other and are subject to selection and to new mutations over generations until equilibrium in gene-frequencies is reached. The mutation-selection equilibrium provides information about mutational load and the differential effects of mutations on a life history trait--the optimal age at maturity. We find that mutations accumulate only at ages with negligible impact on fitness and that mutation accumulation has very little effect on the optimal age at maturity. These results suggest that life histories are largely determined by adaptive processes. The non-adaptive process of mutation accumulation seems to be unimportant at evolutionarily relevant ages.
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Registered trials
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