ArticlePloS one2012
Adaptive evolution in the glucose transporter 4 gene Slc2a4 in Old World fruit bats (family: Pteropodidae).
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- A metaanalysis of bat phylogenetics and positive selection based on genomes and transcriptomes from 18 species.Proceedings of the National Academy of Sciences of the United States of America · 2019Pooled it
- The Road so Far: Tracing the Molecular Evolution of Hexokinase Family in Metazoa.Genome biology and evolution · 2026Article
- Translational lessons from the balanced immune system in bats.Disease models & mechanisms · 2025Review
- Glycation resistance and life-history traits: lessons from non-conventional animal models.Biology letters · 2024Review
- Integrative single-cell characterization of a frugivorous and an insectivorous bat kidney and pancreas.Nature communications · 2024Article
- Comparative genomic analyses illuminate the distinct evolution of megabats within Chiroptera.DNA research : an international journal for rapid publication of reports on genes and genomes · 2020Article
- Robust dengue virus infection in bat cells and limited innate immune responses coupled with positive serology from bats in IndoMalaya and Australasia.Cellular and molecular life sciences : CMLS · 2020Article
- Difference in glucose tolerance between phytophagous and insectivorous bats.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2019Article
- Evolution of Hepatitis B Virus Receptor NTCP Reveals Differential Pathogenicities and Species Specificities of Hepadnaviruses in Primates, Rodents, and Bats.Journal of virology · 2019Article
- Bats: Body mass index, forearm mass index, blood glucose levels and SLC2A2 genes for diabetes.Scientific reports · 2016Article
- Bone-associated gene evolution and the origin of flight in birds.BMC genomics · 2016Article
- Molecular Evolution of the Nuclear Factor (Erythroid-Derived 2)-Like 2 Gene Nrf2 in Old World Fruit Bats (Chiroptera: Pteropodidae).PloS one · 2016Article
- Phosphoenolpyruvate carboxykinase 1 gene (Pck1) displays parallel evolution between Old World and New World fruit bats.PloS one · 2015Article
- Sugar flux through the flight muscles of hovering vertebrate nectarivores: a review.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2014Review
- Relaxed evolution in the tyrosine aminotransferase gene tat in old world fruit bats (Chiroptera: Pteropodidae).PloS one · 2014Article
- Dietary and flight energetic adaptations in a salivary gland transcriptome of an insectivorous bat.PloS one · 2014Article
- The glycogen synthase 2 gene (Gys2) displays parallel evolution between Old World and New World fruit bats.Journal of molecular evolution · 2014Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Frugivorous and nectarivorous bats are able to ingest large quantities of sugar in a short time span while avoiding the potentially adverse side-effects of elevated blood glucose. The glucose transporter 4 protein (GLUT4) encoded by the Slc2a4 gene plays a critical role in transmembrane skeletal muscle glucose uptake and thus glucose homeostasis. To test whether the Slc2a4 gene has undergone adaptive evolution in bats with carbohydrate-rich diets in relation to their insect-eating sister taxa, we sequenced the coding region of the Slc2a4 gene in a number of bat species, including four Old World fruit bats (Pteropodidae) and three New World fruit bats (Phyllostomidae). Our molecular evolutionary analyses revealed evidence that Slc2a4 has undergone a change in selection pressure in Old World fruit bats with 11 amino acid substitutions detected on the ancestral branch, whereas, no positive selection was detected in the New World fruit bats. We noted that in the former group, amino acid replacements were biased towards either Serine or Isoleucine, and, of the 11 changes, six were specific to Old World fruit bats (A133S, A164S, V377F, V386I, V441I and G459S). Our study presents preliminary evidence that the Slc2a4 gene has undergone adaptive changes in Old World fruit bats in relation to their ability to meet the demands of a high sugar diet.
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Registered trials
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