ArticlePloS one2012
Event timing in associative learning: from biochemical reaction dynamics to behavioural observations.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Local 5-HT signaling bi-directionally regulates the coincidence time window for associative learning.Neuron · 2023Article
- The critical balance between dopamine D2 receptor and RGS for the sensitive detection of a transient decay in dopamine signal.PLoS computational biology · 2021Article
- Predictive olfactory learning in Drosophila.Scientific reports · 2021Article
- Identification of Dopaminergic Neurons That Can Both Establish Associative Memory and Acutely Terminate Its Behavioral Expression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Signaling models for dopamine-dependent temporal contiguity in striatal synaptic plasticity.PLoS computational biology · 2020Article
- Reinforcement signaling of punishment versus relief in fruit flies.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Functional architecture of reward learning in mushroom body extrinsic neurons of larval Drosophila.Nature communications · 2018Article
- Calcium in Kenyon Cell Somata as a Substrate for an Olfactory Sensory Memory inFrontiers in cellular neuroscience · 2018Article
- How Swift Is Cry-Mediated Magnetoreception? Conditioning in an American Cockroach Shows Sub-second Response.Frontiers in behavioral neuroscience · 2018Article
- Article
- Reversing Stimulus Timing in Visual Conditioning Leads to Memories with Opposite Valence in Drosophila.PloS one · 2015Article
- Differences in long-term memory stability and AmCREB level between forward and backward conditioned honeybees (Apis mellifera).Frontiers in behavioral neuroscience · 2015Article
- Pain-relief learning in flies, rats, and man: basic research and applied perspectives.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Review
- Trace conditioning in insects-keep the trace!Frontiers in physiology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Associative learning relies on event timing. Fruit flies for example, once trained with an odour that precedes electric shock, subsequently avoid this odour (punishment learning); if, on the other hand the odour follows the shock during training, it is approached later on (relief learning). During training, an odour-induced Ca(++) signal and a shock-induced dopaminergic signal converge in the Kenyon cells, synergistically activating a Ca(++)-calmodulin-sensitive adenylate cyclase, which likely leads to the synaptic plasticity underlying the conditioned avoidance of the odour. In Aplysia, the effect of serotonin on the corresponding adenylate cyclase is bi-directionally modulated by Ca(++), depending on the relative timing of the two inputs. Using a computational approach, we quantitatively explore this biochemical property of the adenylate cyclase and show that it can generate the effect of event timing on associative learning. We overcome the shortage of behavioural data in Aplysia and biochemical data in Drosophila by combining findings from both systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.