ArticleFrontiers in microbiology2012
Organic Acid Excretion in Penicillium ochrochloron Increases with Ambient pH.
Article in Frontiers in microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- From beet molasses to malic acid: holistic development of fermentation and downstream process.Biotechnology for biofuels and bioproducts · 2026Article
- Understanding the Role of pH Regulation and Neutralizing Agents in Organic Acid Production and Growth of Aspergillus oryzae.Biotechnology and bioengineering · 2026Article
- Effects of Bacterial and Fungal Inocula on Biomass, Ecophysiology, and Uptake of Metals ofPlants (Basel, Switzerland) · 2023Article
- Genome-wide comparison deciphers lifestyle adaptation and glass biodeterioration property of Curvularia eragrostidis C52.Scientific reports · 2022Article
- Organic acid, a virulence factor for pathogenic fungi, causing postharvest decay in fruits.Molecular plant pathology · 2022Review
- Xanthoepocin, a photolabile antibiotic of Penicillium ochrochloron CBS 123823 with high activity against multiresistant gram-positive bacteria.Microbial cell factories · 2022Article
- Enhanced l-Malic Acid Production byFrontiers in bioengineering and biotechnology · 2021Article
- Overflow Metabolism inFrontiers in fungal biology · 2021Article
- Challenging the charge balance hypothesis: reconsidering buffer effect and reuptake of previously excreted organic acids by Penicillium ochrochloron.FEMS microbiology letters · 2020Article
- Critical evaluation of a putative glucosamine excretion by Aspergillus niger CBS120.49 and Penicillium ochrochloron CBS123.824 under citric acid producing conditions.Scientific reports · 2019Article
- ContinuousFrontiers in molecular biosciences · 2019Article
- Fungal Growth in Batch Culture - What We Could Benefit If We Start Looking Closer.Frontiers in microbiology · 2019Article
- World market and biotechnological production of itaconic acid.3 Biotech · 2018Review
- The Dynamics of Plasma Membrane, Metabolism and Respiration (PM-M-R) inFrontiers in microbiology · 2017Article
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Authors and funding
5 authors.
Funding
Abstract
Despite being of high biotechnological relevance, many aspects of organic acid excretion in filamentous fungi like the influence of ambient pH are still insufficiently understood. While the excretion of an individual organic acid may peak at a certain pH value, the few available studies investigating a broader range of organic acids indicate that total organic acid excretion rises with increasing external pH. We hypothesized that this phenomenon might be a general response of filamentous fungi to increased ambient pH. If this is the case, the observation should be widely independent of the organism, growth conditions, or experimental design and might therefore be a crucial key point in understanding the function and mechanisms of organic acid excretion in filamentous fungi. In this study we explored this hypothesis using ammonium-limited chemostat cultivations (pH 2-7), and ammonium or phosphate-limited bioreactor batch cultivations (pH 5 and 7). Two strains of Penicillium ochrochloron were investigated differing in the spectrum of excreted organic acids. Confirming our hypothesis, the main result demonstrated that organic acid excretion in P. ochrochloron was enhanced at high external pH levels compared to low pH levels independent of the tested strain, nutrient limitation, and cultivation method. We discuss these findings against the background of three hypotheses explaining organic acid excretion in filamentous fungi, i.e., overflow metabolism, charge balance, and aggressive acidification hypothesis.
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