ArticleFrontiers in physiology2012
Neuroprotective effects of 17β-estradiol rely on estrogen receptor membrane initiated signals.
Article in Frontiers in physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 59 citations in OpenAlex.
- Estrogen deprivation exacerbates Alzheimer's disease pathology through neuronal CTSS signaling.Journal of neuroinflammation · 2026Article
- Association of Menopause and Hormone Replacement Therapy with Hearing Loss.The Annals of otology, rhinology, and laryngology · 2026Article
- Focal Estrogen Therapy in Male Rats Promotes Neuronal Survival and Reduces Denervation Atrophy After Spinal Cord Injury via Modulation of β-Catenin and NF-κB.Neurochemical research · 2026Article
- Article
- Mechanisms Underlying Treatment-Resistant Depression: Exploring Sex-Based Biological Differences.Journal of neurochemistry · 2025Review
- Estradiol Prevents Amyloid Beta-Induced Mitochondrial Dysfunction and Neurotoxicity in Alzheimer's Disease via AMPK-Dependent Suppression of NF-κB Signaling.International journal of molecular sciences · 2025Article
- Role of Neuroglobin in the Neuroprotective Actions of Estradiol and Estrogenic Compounds.Cells · 2021Review
- Sexual hormones regulate the redox status and mitochondrial function in the brain. Pathological implications.Redox biology · 2020Review
- Auditory function and dysfunction: estrogen makes a difference.Cellular and molecular life sciences : CMLS · 2020Review
- Age-specific associations between oestradiol, cortico-amygdalar structural covariance, and verbal and spatial skills.Journal of neuroendocrinology · 2019Article
- Interactions of Aromatase and Seladin-1: A Neurosteroidogenic and Gender Perspective.Translational neuroscience · 2019Article
- Beyond the Antioxidant Activity of Dietary Polyphenols in Cancer: the Modulation of Estrogen Receptors (ERs) Signaling.International journal of molecular sciences · 2018Review
- Combined effects of rat Schwann cells and 17β-estradiol in a spinal cord injury model.Metabolic brain disease · 2018Article
- Huntingtin polyQ Mutation Impairs the 17β-Estradiol/Neuroglobin Pathway Devoted to Neuron Survival.Molecular neurobiology · 2017Article
- Estrogen receptor beta polymorphisms and cognitive performance in women: associations and modifications by genetic and environmental influences.Journal of neural transmission (Vienna, Austria : 1996) · 2016Article
- The Deleterious Effects of Oxidative and Nitrosative Stress on Palmitoylation, Membrane Lipid Rafts and Lipid-Based Cellular Signalling: New Drug Targets in Neuroimmune Disorders.Molecular neurobiology · 2016Review
- G-1 exerts neuroprotective effects through G protein-coupled estrogen receptor 1 following spinal cord injury in mice.Bioscience reports · 2016Article
- Rescue from Sexually Dimorphic Neuronal Cell Death by Estradiol and PI3 Kinase Activity.Cellular and molecular neurobiology · 2016Article
- Estrogen/Huntingtin: a novel pathway involved in neuroprotection.Neural regeneration research · 2016Article
- Selective regulation of neurosteroid biosynthesis under ketamine-induced apoptosis of cortical neurons in vitro.Molecular medicine reports · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Besides its crucial role in many physiological events, 17β-estradiol (E2) exerts protective effects in the central nervous system. The E2 effects are not restricted to the brain areas related with the control of reproductive function, but rather are widespread throughout the developing and the adult brain. E2 actions are mediated through estrogen receptors (i.e., ERα and ERβ) belonging to the nuclear receptor super-family. As members of the ligand-regulated transcription factor family, classically, the actions of ERs in the brain were thought to mediate only the E2 long-term transcriptional effects. However, a growing body of evidence highlighted rapid, membrane initiated E2 effects in the brain that are independent of ER transcriptional activities and are involved in E2-induced neuroprotection. The aim of this review is to focus on the rapid effects of E2 in the brain highlighting the specific role of the signaling pathway(s) of the ERβ subtype in the neuroprotective actions of E2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.