ArticleWorld journal of gastroenterology2012
A rare case of langerhans cell histiocytosis of the gastrointestinal tract.
Article in World journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Langerhans cell histiocytosis in the adult lower gastrointestinal tract.BMJ case reports · 2026Article
- Adult Langerhans Cell Histiocytosis Presenting as an Isolated Rectal Polyp and Hematochezia.Cureus · 2026Article
- Manifestations and outcomes of digestive tract involvement in adult Langerhans cell histiocytosis.Annals of hematology · 2024Article
- Gastrointestinal LCH: a rare manifestation of Langerhans cell histiocytosis.Annals of medicine and surgery (2012) · 2024Article
- Relapse of Non-Gastrointestinal Langerhans Cell Histiocytosis in the Rectum in a Child: A Case Report.Clinical medicine insights. Case reports · 2023Article
- Gastrointestinal Langerhans cell histiocytosis with unifocal, single-system involvement in adults: Cases report and literature review.Journal of clinical laboratory analysis · 2022Article
- Langerhans Cell Histiocytosis with the Synchronous Invasion of Stomach and Colon in an Adult Patient: A Case Report.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2022Article
- Unifocal Gastric Langerhans Cell Histiocytosis in a Child-A Unique Case to Remember.JPGN reports · 2022Article
- Article
- Isolated Langerhans cell histiocytosis of the stomach: a case report and literature review.International journal of clinical and experimental pathology · 2018Article
- Cutaneous Langerhans cell histiocytosis with gastrointestinal involvement treated with dabrafenib.JAAD case reports · 2018Article
- Adult Langerhans cell histiocytosis with pulmonary and colorectoanal involvement: a case report.Journal of medical case reports · 2017Article
- A rare presentation of langerhans cell histiocytosis tonsil infiltration: review of the literature: atypical presentation of langerhans cell histiocytosis.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2014Article
- A case of thymic Langerhans cell histiocytosis with diabetes insipidus as the first presentation.Frontiers of medicine · 2013Article
- Adult Langerhans cell histiocytosis presenting as metachronous colonic polyps.Autopsy & case reportsArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the proliferation of specialized, bone marrow-derived langerhans cells and mature eosinophils. The clinical spectrum ranges from an acute, fulminant, disseminated disease called Letterer-Siwe disease to solitary or few, indolent and chronic lesions of the bone or other organs called eosinophilic granuloma. Involvement of the gastrointestinal tract is very rare in LCH. We present the case of a 53-year-old woman referred by her primary care physician for a screening colonoscopy. A single sessile polyp, measuring 4 mm in size, was found in the rectum. Histopathological examination revealed that the lesion was relatively well circumscribed and comprised mainly a mixture of polygonal cells with moderate-to-abundant pink slightly granular cytoplasm. The nuclei within these cells had frequent grooves and were occasionally folded. Immunohistochemical staining was positive for CD-1a which confirmed the diagnosis of LCH. On further workup, there was no evidence of involvement of any other organ. On follow up colonoscopy one year later, there was no evidence of disease recurrence. Review of the published literature revealed that LCH presenting as solitary colonic polyp is rare. However, with the increasing rates of screening colonoscopy, more colonic polyps may be identified as LCH on histopathology. This underscores the importance of recognizing this rare condition and ensuring proper follow-up to rule out systemic disease.
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